Principal Scientist, Gene Editing (Protein Design)

Principal Scientist, Gene Editing

We are seeking a highly motivated and skilled Associate Director to join our Gene Editing team to develop innovative CRISPR-based therapeutics for treating diseases. You will work with colleagues from the protein engineering, biology, and early translation teams to develop and validate therapeutic strategies for CRISPR-based therapeutics. This position is ideal for a candidate with a passion for cutting-edge science and a desire to make a significant impact on Ensoma's therapeutic products as we seek to revolutionize treatments for patients with genetic diseases in the hemopoietic cell system.

Responsibilities:

• Conduct protein design activities, incorporating state-of-the-art approaches like structural biology and/or AI
• Design and execute mid/high-throughput screening assays in bacterial settings to identify novel CRISPR-based editing systems and optimize their performance for treating diseases.
• Optimize and troubleshoot screening protocols to improve sensitivity, specificity, and reproducibility.
• Test selected editors in cell line and primary cells
• Analyze and interpret screening data (NGS) and communicate results to the project team
• Complete laboratory experiments in timely fashion, including maintaining and producing a complete and accurate experimental records
• Participate in scientific discussions with the rest of the organization and present recent findings
• Other duties and responsibilities as assigned

Qualifications:

Required:

• A Doctoral Degree in biochemistry, molecular biology or related field with a minimum of eight years of experience in the biotechnology/pharmaceutical industry and/or an academic setting (industry experience is preferred)
• Experience in protein design via structural biology and/or AI approaches
• Experience with experimental work using bacterial models e.g. Escherichia coli
• Experience with common DNA cloning techniques
• Experience with cell biology and editing techniques

Preferred:

• Experience with Escherichia coli functional selections, directed evolution, or likewise
• Familiarity with programming (python, R, etc.), bioinformatics or protein structural analysis
• Experience with synthesis and/or handling of large variant DNA libraries
• Experience with CRISPR systems and gene editing

About Ensoma:

Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask: What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?

Ensoma was founded to answer these questions through our Engenious™ platform that can transform the hematopoietic (blood & immune) system with a single treatment. Our Engenious gene therapy platform is the first to precisely engineer any or all hematopoietic and immune cells with a one-time, off-the-shelf in vivo treatment. Engenious therapies have an unmatched capacity to deliver all modern genetic modification tools and set a new standard for versatile cell programming and control across a range of complex diseases. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.

For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell and gene therapy field, we feel an urgency and passion for our work driven by its potential global impact.

A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.

Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts. For more information, please visit www.ensoma.com.