Principal Associate Scientist Gene Therapy

Job Description Execute the production of AAV in adherent and suspension mammalian systems. Execute validated protocols for the purification of AAV preps (ultracentrifugation or chromatography based) and perform characterization using standard molecular biology and biochemistry techniques. Support process development for the refinement of the existing upstream and downstream SOPs. Manage CROs (Contract Research Organizations) for external AAV vector production. Maintain accurate laboratory records, present data to the team and coauthor internal reports and scientific communications. Qualifications: Minimum Requirements: Employer will accept a Master of Science degree (or foreign equivalent) in Biology, Biochemistry, Biotechnology or related field and 2 years of experience in the job offered or in a Sr. Associate Scientist, Gene Therapy-related occupation. Alternatively, employer will accept a Bachelor of Science degree (or foreign equivalent) in Biology, Biochemistry, Biotechnology or a related field and 4 years of experience in the job offered or in a Sr. Associate Scientist, Gene Therapy-related occupation. Position requires 24 months of experience in the following: Demonstrated strong proficiency with general molecular biology and biochemistry techniques, including at least three of the following: cloning, PCR, qPCR, ddPCR, RNA analysis, WB, or ELISA. Demonstrated extensive experience with AAV or recombinant protein production in adherent mammalian cells (bench scale). Demonstrated experience with AAV/recombinant protein production in suspension cell lines. Hands on experience with chromatography and/or AKTA systems. Demonstrated proficiency with large scale (5-10L) plasmid DNA purification and troubleshooting. Additional Information: All your information will be kept confidential according to EEO guidelines. Why Biogen? We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives. At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

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