Mammoth Biosciences, Inc.
Scientist II/Senior Scientist I - Nucleic Acid Detection
Mammoth Biosciences, Inc., California, Missouri, United States, 65018
OPPORTUNITYMammoth’s Assay Development team is hiring a Scientist II/Sr. Scientist I to develop nucleic acid testing assays to support the development of novel CRISPR-based therapeutics. The successful candidate will develop, optimize, and routinely execute DNA and RNA quantification assays and contribute to de novo assay development. This position requires a strong background in plate based assays, excellent problem-solving skills, analytical thinking, and the ability to work collaboratively in a fast-paced environment.KEY RESPONSIBILITIES
Contribute creatively to the design and development of novel assays for characterizing therapeutic nucleic acids for CRISPR-based therapiesDevelop scalable and rigorous assays for measuring gene expression, RNA stability and degradation, pharmacokinetics, and therapeutic efficacyLiaise with CROs to qualify and validate assays developed by the teamRoutinely develop standardized protocols for assaysPlan, design, execute and designate assays for CRISPR therapeutic developmentProvide consultation to other program teams on dPCR, ddPCR, qPCR, RNA-seq and other relevant assays routinely used in early research and later stage drug developmentTrain and provide instructions to junior members of assay development and associated teams on assaysDocument experiments in electronic lab notebooks and present data when neededProvide support to automation team scientists to onboard protein detection protocols to high throughput systemsLead team and routinely develop and improve processes to better team functionalityREQUIRED QUALIFICATIONS
PhD in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or related fields with 3+ years of relevant professional experience in industry or academia following completion of PhD. For non-PhD candidates, an MS degree with 6+ years of professional experience is required.At least 3 years of hands-on experience with digital PCR, qRT-PCR, droplet digital PCR, RNA-seq and other nucleic acid based molecular biology techniques2+ years of hands-on experience in at least two of the following areas: NAT assay validation and qualification; Design and implementation and novel DNA and RNA quantification methods; Generating robust standardized protocols and SOPs as release assaysPREFERRED QUALIFICATIONS
Background in transcriptome analyses, RNA-seq, single cell RNA-seqPrior experience with CRO managementPrior experience filing INDs for gene therapiesBackground knowledge of CRISPR-based gene editing therapies and modalities including insertions, base and prime editing, and epigenetic editing1+ years of experience managing direct reportsWorking proficiency with common software and data analysis tools (Benchling, Excel, GraphPad Prism, JMP, Biorender)Strong verbal and written communication skillsActive engagement with concepts of diversity and inclusionBENEFITS
Company-paid health/vision/dental benefitsUnlimited vacation and generous sick timeCompany-sponsored meals and snacksWellness, caregiver and ergonomics benefits401(k) with company matchingBase Salary Range: $135,000 - $155,000Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.COMPANYMammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable
in vivo
gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential
in vivo
gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.
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Contribute creatively to the design and development of novel assays for characterizing therapeutic nucleic acids for CRISPR-based therapiesDevelop scalable and rigorous assays for measuring gene expression, RNA stability and degradation, pharmacokinetics, and therapeutic efficacyLiaise with CROs to qualify and validate assays developed by the teamRoutinely develop standardized protocols for assaysPlan, design, execute and designate assays for CRISPR therapeutic developmentProvide consultation to other program teams on dPCR, ddPCR, qPCR, RNA-seq and other relevant assays routinely used in early research and later stage drug developmentTrain and provide instructions to junior members of assay development and associated teams on assaysDocument experiments in electronic lab notebooks and present data when neededProvide support to automation team scientists to onboard protein detection protocols to high throughput systemsLead team and routinely develop and improve processes to better team functionalityREQUIRED QUALIFICATIONS
PhD in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or related fields with 3+ years of relevant professional experience in industry or academia following completion of PhD. For non-PhD candidates, an MS degree with 6+ years of professional experience is required.At least 3 years of hands-on experience with digital PCR, qRT-PCR, droplet digital PCR, RNA-seq and other nucleic acid based molecular biology techniques2+ years of hands-on experience in at least two of the following areas: NAT assay validation and qualification; Design and implementation and novel DNA and RNA quantification methods; Generating robust standardized protocols and SOPs as release assaysPREFERRED QUALIFICATIONS
Background in transcriptome analyses, RNA-seq, single cell RNA-seqPrior experience with CRO managementPrior experience filing INDs for gene therapiesBackground knowledge of CRISPR-based gene editing therapies and modalities including insertions, base and prime editing, and epigenetic editing1+ years of experience managing direct reportsWorking proficiency with common software and data analysis tools (Benchling, Excel, GraphPad Prism, JMP, Biorender)Strong verbal and written communication skillsActive engagement with concepts of diversity and inclusionBENEFITS
Company-paid health/vision/dental benefitsUnlimited vacation and generous sick timeCompany-sponsored meals and snacksWellness, caregiver and ergonomics benefits401(k) with company matchingBase Salary Range: $135,000 - $155,000Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.COMPANYMammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable
in vivo
gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential
in vivo
gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.
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