Mirai Bio | Cambridge, MA Senior Scientist, Translational

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!Position Summary :Mirai Bio is actively seeking a highly skilled and dedicated Translational Senior Research Scientist to join our dynamic team developing the next generation of nucleic acid medicines. You will play a critical role in the discovery and development of Mirai’s lipid nanoparticle delivery platform progressing our cellular targeting and cargo encapsulation technologies. The successful application will have the opportunity to work with an experienced and highly collaborative team in a fast-paced cross-functional team environment.Key Responsibilities:Design, optimize, execute in vitro, ex vivo and in vivo biological and immunological assays, including characterization of diverse primary cell populations from rodent and human tissues, co-cultures, reporter assays (e.g. cell killing) using methods such as but not limited to multi-color flow cytometry.Design and evaluate moieties for targeting LNPs to specific cell types under in vivo delivery.Independently analyze own research data, solve problems with minimal guidance and effectively plan follow up experiments.Align with stakeholder goals to meet tight timelines and provides direction to research associates/ junior scientists or members of project teams in the initiation and execution of scientific experimentation to collectively achieve team goals.Makes contributions to scientific literature through publication and conference attendance.Maintain clear and accurate documentations in an electronic lab notebook or other technical reporting format.Prepare detailed protocols and SOPs to enable transfer of assays.Basic Qualifications:PhD Degree in a Life Sciences (Cell Biology, Immunology or related) area with a minimum of 5 years of laboratory experience in an academic or industry setting.Extensive hands-on experience with maintaining cultures of mammalian cell lines and primary cells.Extensive hands-on experience with handling human blood, isolating primary cells from various tissues.Extensive hands-on experience with immunological assays (e.g. ELISA, Luminex, cell proliferation, cell killing) and multi-color flow cytometry.Experience with protein engineering and design based on natural and synthetic binders.Independent thinker, with excellent attention to details; ability to work independently and make critical decisions.Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial setting.Strong written and oral communication skills. Able to communicate effectively with a multi-disciplinary team.Demonstrated ability to follow established policies and to keep accurate, and complete records.Ability to routinely handle tissues and biological samples from rodents and human donors.Experience with immunofluorescence staining and histology is preferred.Experience with lipid nanoparticles formulation is preferred.Prior industry working experience is preferred.About FlagshipFlagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.Flagship Pioneering and our ecosystem companies are

committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

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