Postdoctoral Fellow - scRNAsequencing

GENERAL SUMMARY/ OVERVIEW STATEMENT:The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is a bold one: to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued and advanced every day by a group of highly motivated individuals. The Ragon Institute, at every level, depends upon collaboration, compassion, dedication, and innovation. It is a results-oriented organization that seeks people who not only embrace these values but who thrive in teams and want to work in a dynamic environment.The Kwon Laboratory (www.kwonlab.org) at the Ragon Institute of MGH, MIT and Harvard at the Massachusetts General Hospital in Cambridge, MA has an opening for a highly motivated postdoctoral fellow to study mechanistic links between the vaginal microbiome and adverse reproductive outcomes using single cell RNA sequencing of mucosal samples from the female genital tract. This includes examination of the role of the vaginal microbiome that impacts host mucosal immunity and HIV acquisition risk. The person hired will work under the supervision of Dr. Kwon conducting patient-oriented translational research utilizing large, well-characterized patient cohorts based in the US and sub-Saharan Africa to understand host-microbiota interactions and their impact on HIV, pregnancy, fertility, and cancer.The project will specifically involve the use of cutting-edge technologies such as single cell RNA sequencing and bioinformatics. The fellow will be based at the Ragon Institute in Cambridge, MA USA with frequent opportunities to work in Durban, South Africa.Candidates will have ample opportunities to acquire and develop new skills, work closely with the PI and collaborators, and communicate results to the scientific community through conference presentations and peer-reviewed publications while working in a supportive, highly collaborative, and energetic environment. State-of-the-art facilities are available within an exceptionally energetic research setting at the Ragon Institute, which is part of Massachusetts General Hospital, the Massachusetts Institute of Technology, and Harvard Medical School.PRINCIPAL DUTIES AND RESPONSIBILITIES:Under the direction of the principal investigator, the applicant will independently carry out activities performing research. Specifically, a large effort in the lab is underway to integrate and analyze a multiomic dataset from thousands of samples from a prospective study with thousands of participants of the vaginal microbiome, mucosal immune state, and health outcomes. Duties include:Integrate and organize existing data from many modalities, including 16S amplicons, shotgun metagenomics, multiplex ELISA, metabolomics, and more.Interface with researchers in the lab generating new data and continuously process raw data to assess the quality of new data.Lead the biological analysis and interpretation of the data of these multiple modalities.Work closely within the group and with outside collaborators.Mentor students and technicians.Maintain close communications with the PI regarding progress.Write, edit, and submit manuscripts/abstracts detailing the results of the project.Demonstrate integrity, excellence, accountability and teamwork in all interactions.QualificationsMinimum degree and field of knowledge:

PhD requiredYears of experience required:

3 or more years of relevant experienceQualifications:A Ph.D. and/or M.D. with relevant experience in single cell sequencing and bioinformatics.Experience in integrating multiple data types from many samples, with an understanding of raw-data generation and bioinformatic processing, as well as downstream analysis of high-dimensional multimodal data.Highly motivated and independent, with the ability to work in a dynamic team environment.Exceptional organizational skills and excellent attention to detail.Strong oral and written communications skills.Must have good interpersonal skills.EEO Statement:Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.Primary Location:

MA-Cambridge-MGH Ragon InstituteWork Locations:MGH Ragon Institute600 Main StCambridge02139Job:

MD/PHD/Fellows/PostDocsOrganization:

Mass General Physicians Organization (MGPO)Schedule:

Full-timeStandard Hours:

40Shift:

Day JobEmployee Status:

RegularRecruiting Department:

Ragon InstituteJob Posting:

Sep 26, 2024

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