Senior Scientist, Chemistry

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance the next generation of RNA therapeutics.Primary Responsibilities Include:Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve

in vivo

proof of concept; Develop efficient and scalable synthetic methods and routes.Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.Act as a key member of a multidisciplinary RNA research team, assisting with the development of project strategy, and analysis and communication of complex data.Serve as an in-house oligonucleotide and delivery chemistry expert.Drive the writing of technical reports to support patent applications and manuscript preparations.Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.Organize workstreams and complete individual and team objectives to maintain project timelines.Supervise and mentor junior staff.Desired Education and Skills:The ideal candidate will have a PhD in organic chemistry, biochemistry, or related fields with 4+ years of relevant post-doctoral or industry experience; or M.S. with 8+ years of experience.Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.This position requires work on site at one of Sarepta's facilities in the United States. The targeted salary range for this position is $120,000 - $150,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

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