Pfizer
Senior Principal Scientist - In Vivo Pharmacology Lead-Seattle Metro Area
Pfizer, Bothell, Washington, United States, 98021
POSITION SUMMARY
This position is based at our Bothell, WA site which is approximately 15 miles from the downtown Seattle area.
You will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key stakeholder/ contributor to the
In Vivo
Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives. You will directly supervise laboratory staff that make up an
in vivo
team responsible for study execution and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in
in vivo
pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery. POSITION RESPONSIBILITIES Collaborate across project teams to establish
in vivo
strategy and study plans for drug discovery projects. Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical
in vivo
data to enable project stage dependent decisions. Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy. Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology. Design and conduct
in vivo
studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis. Supervise and guide a small team of scientists. Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies. Ensure team members comply with all regulatory requirements and internal policies. Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary. Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment. Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings. QUALIFICATIONS Must-Have Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline. Minimum 8 years industry experience including technical and scientific experience in drug discovery and preclinical development. Experience in collaborative research in Oncology drug discovery programs. Experience with animal models of human cancers. Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA). Experience supervising a small team of Scientists. Excellent written and oral communication and presentation skills. Proficiency with all common office and scientific software. Preferred Strong track record of publications or evidence of equivalent achievements in industry. Experience with GEMM and humanized models. Experience with Antibody Drug Conjugates (ADC). Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. PHYSICAL/MENTAL REQUIREMENTS Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses). NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Must be willing and able to work after hours as needed to ensure study integrity. Relocation support available. Work Location Assignment: On Premise. The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Relocation assistance may be available based on business needs and/or eligibility. SUNSHINE ACT Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & EMPLOYMENT ELIGIBILITY Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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In Vivo
Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives. You will directly supervise laboratory staff that make up an
in vivo
team responsible for study execution and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in
in vivo
pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery. POSITION RESPONSIBILITIES Collaborate across project teams to establish
in vivo
strategy and study plans for drug discovery projects. Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical
in vivo
data to enable project stage dependent decisions. Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy. Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology. Design and conduct
in vivo
studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis. Supervise and guide a small team of scientists. Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies. Ensure team members comply with all regulatory requirements and internal policies. Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary. Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment. Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings. QUALIFICATIONS Must-Have Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline. Minimum 8 years industry experience including technical and scientific experience in drug discovery and preclinical development. Experience in collaborative research in Oncology drug discovery programs. Experience with animal models of human cancers. Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA). Experience supervising a small team of Scientists. Excellent written and oral communication and presentation skills. Proficiency with all common office and scientific software. Preferred Strong track record of publications or evidence of equivalent achievements in industry. Experience with GEMM and humanized models. Experience with Antibody Drug Conjugates (ADC). Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. PHYSICAL/MENTAL REQUIREMENTS Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses). NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Must be willing and able to work after hours as needed to ensure study integrity. Relocation support available. Work Location Assignment: On Premise. The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Relocation assistance may be available based on business needs and/or eligibility. SUNSHINE ACT Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & EMPLOYMENT ELIGIBILITY Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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