Immunome, Inc.
Senior / Principal Scientist, Purification
Immunome, Inc., Bothell, Washington, United States, 98021
Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025.
Position Overview
The Senior / Principal Scientist in the Purification Team within Antibody Sciences will be essential to advancing our drug development pipeline. You will play a crucial role in our ongoing programs and help shape the development of novel therapeutic technologies. The modalities will include not only antibodies but also conjugated forms with various linkers and payloads, each with distinct physical properties. As the leader of the purification development group, you will leverage your strong expertise to develop robust system and deliver high-quality materials that support animal studies and ensure the functional teams can continue to drive projects forward.
Responsibilities
Research Design and Execution
Effectively lead a team in generating original technical ideas and developing strategies.
Lead the development, optimization, and scale-up of purification processes for biologic candidates to support both early- and late-stage development.
Oversee purification strategies for biologic candidates and take full accountability for project deliverables.
Independently operate and possess strong knowledge of TFF systems and AKTA chromatography skid systems, with proficient hands-on experience in clarification equipment.
Perform routine downstream purification operations related to AKTA chromatography systems, including system setup, assembly/disassembly, system cleanup, in-process sampling, buffer preparation, and troubleshooting of operational and equipment issues.
Data Analysis and Interpretation
Analyze and summarize experimental data from protein quality, quantity, stability, and viscosity assays.
Interpret results and communicate their implications for technology development.
Familiarity with LIMS (Laboratory Information Management System) for data management.
Project Collaboration
Collaborate with colleagues from diverse scientific disciplines, including biology, chemistry, pharmacology, and translational medicine to achieve project goals.
Organize data for ease of collaboration with other research teams.
Documentation and Reporting:
Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
Prepare and present research findings to internal teams a contribute to project updates and strategic discussions.
Continuous Learning and Development:
Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics.
Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.
Qualifications
Bachelor’s, Master’s, or PhD in molecular biology, biochemistry, biophysics, or related field.
Minimum of 12 years of experience (or 8+ years of experience with a Master’s degree, or 5+ with a PhD) in preclinical drug development in the biotechnology or pharmaceutical industry.
Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI is required. Large scale is necessary.
Knowledge and Skills
Ability to maintain detailed and organized experimental logs.
Ability to understand and communicate complex scientific data.
Ability to collaborate effectively in a team-oriented environment.
Ability to maintain system stability and performance.
Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI.
A thorough knowledge of protein stability, degradation mechanisms and excipients is a plus.
Deep expertise in ultrafiltration/diafiltration (UF/DF) and tangential flow filtration (TFF) is a strong plus.
Experience in CRO management is a plus.
A solid track record of peer-reviewed publications and presentations at national-level conferences is a plus.
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025.
Position Overview
The Senior / Principal Scientist in the Purification Team within Antibody Sciences will be essential to advancing our drug development pipeline. You will play a crucial role in our ongoing programs and help shape the development of novel therapeutic technologies. The modalities will include not only antibodies but also conjugated forms with various linkers and payloads, each with distinct physical properties. As the leader of the purification development group, you will leverage your strong expertise to develop robust system and deliver high-quality materials that support animal studies and ensure the functional teams can continue to drive projects forward.
Responsibilities
Research Design and Execution
Effectively lead a team in generating original technical ideas and developing strategies.
Lead the development, optimization, and scale-up of purification processes for biologic candidates to support both early- and late-stage development.
Oversee purification strategies for biologic candidates and take full accountability for project deliverables.
Independently operate and possess strong knowledge of TFF systems and AKTA chromatography skid systems, with proficient hands-on experience in clarification equipment.
Perform routine downstream purification operations related to AKTA chromatography systems, including system setup, assembly/disassembly, system cleanup, in-process sampling, buffer preparation, and troubleshooting of operational and equipment issues.
Data Analysis and Interpretation
Analyze and summarize experimental data from protein quality, quantity, stability, and viscosity assays.
Interpret results and communicate their implications for technology development.
Familiarity with LIMS (Laboratory Information Management System) for data management.
Project Collaboration
Collaborate with colleagues from diverse scientific disciplines, including biology, chemistry, pharmacology, and translational medicine to achieve project goals.
Organize data for ease of collaboration with other research teams.
Documentation and Reporting:
Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
Prepare and present research findings to internal teams a contribute to project updates and strategic discussions.
Continuous Learning and Development:
Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics.
Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.
Qualifications
Bachelor’s, Master’s, or PhD in molecular biology, biochemistry, biophysics, or related field.
Minimum of 12 years of experience (or 8+ years of experience with a Master’s degree, or 5+ with a PhD) in preclinical drug development in the biotechnology or pharmaceutical industry.
Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI is required. Large scale is necessary.
Knowledge and Skills
Ability to maintain detailed and organized experimental logs.
Ability to understand and communicate complex scientific data.
Ability to collaborate effectively in a team-oriented environment.
Ability to maintain system stability and performance.
Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI.
A thorough knowledge of protein stability, degradation mechanisms and excipients is a plus.
Deep expertise in ultrafiltration/diafiltration (UF/DF) and tangential flow filtration (TFF) is a strong plus.
Experience in CRO management is a plus.
A solid track record of peer-reviewed publications and presentations at national-level conferences is a plus.
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr