Bicycle Therapeutics
Senior Director, Global Medical Affairs Strategy
Bicycle Therapeutics, Cambridge, Massachusetts, us, 02140
Company Description
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA USA
Culture
is key and all Bicycle employees actively embrace and role model our company values:
We are
Adventurous . We believe it’s the way to deliver extraordinary results for our patients.
We are
Dedicated to our Mission . You can’t change the world if you don’t have determination.
We are
One Team . We only succeed when we work together.
Job Description
The Senior Director, Global Medical Affairs Strategy is a key member of the Medical Affairs leadership team and will function as a scientific and medical expert for Medical Affairs, as well as other groups across the company. This individual will be responsible for developing and executing the overall global medical affairs strategy and tactical plans for the current and future Bicycle portfolio. This role will include overseeing the development of global medical affairs plans and cross-functional integrated evidence plans. This leader will provide strategic input into the Global Product Teams (GPTs), either directly or through oversight of the medical affairs representation on GPTs. The successful candidate will have a successful track record of developing and driving medical strategy for multiple assets, including the effective communication of scientific data through publications, medical communications, scientific engagement, advisory boards, congress activities, and medical information. In addition, the Senior Director will support data generation and life cycle management activities as well as develop relationships with global thought leaders in support of programs. This individual will be an experienced people manager, who will lead the global medical affairs strategy function and effectively collaborate across the company.
Lead the development and execution of annual and long-range global medical affairs strategies and tactics to support the clinical development of the portfolio and prepare for future launch readiness
Develop and execute strategy for the utilization of scientific data generated by preclinical, clinical, and Real-World Evidence (RWE) studies
Establish the Global Medical Affairs Team (GMAT) structure and cadence at Bicycle to develop and execute on medical strategies and tactic
Lead cross-functional GMAT teams directly or through oversight of other medical strategy team members to develop and implement integrated medical strategy for Bicycle products
Ensure medical affairs strategy collaboration and strategic alignment with the field medical affairs team and support scientific communication material development to support KOL engagement
Take accountability for the Investigator-Sponsored Trial (IST) strategy for Bicycle programs and serve as a key individual in the development, roll-out, and operation of IST programs
Provide advice to the Medical, Legal, and Regulatory (MLR) review team and resolve escalations
Assure close but appropriate coordination of medical affairs strategies and activities with clinical development, clinical operations, commercial, translational, research, corporate communications, investor relations, and other key Bicycle stakeholders
Provide strategic oversight and assist as needed, in the development of publications (i.e., abstracts, presentations, manuscripts), integrated evidence plans, lifecycle management plans, congress plans, medical education plans, SOPs, ISTs, budgets, and RWE/HEOR plans\
Present at scientific advisory boards and internal/external meetings
Qualifications
Prior biopharmaceutical industry experience is required (10+ years of experience preferred) in medical affairs and oncology drug development
Advanced degree in health-related field (MD, PhD, or PharmD preferred)
Strong leadership skills with track-record of building and managing effective teams
Ability to think strategically and translate scientific information into medical affairs strategies
Ability to understand complex information and simplify into concise scientific messages
Ability to navigate and succeed in a dynamic, fast-paced environment with a high degree of collaboration and teamwork
Open, engaging, and transparent with ability resolve conflict
Global perspective and mindset with ability work with colleagues and stakeholders from various cultures, backgrounds, and geographies
Strategic thinking with strong business acumen and the ability to prioritize
Excellent communication and presentation skills with the ability to influence key stakeholders
Proficiency in clinical trial data review and interpretation
Knowledge of U.S. and ex-U.S. healthcare systems
Occasional business travel required (~25%)
Additional Information
Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA USA
Culture
is key and all Bicycle employees actively embrace and role model our company values:
We are
Adventurous . We believe it’s the way to deliver extraordinary results for our patients.
We are
Dedicated to our Mission . You can’t change the world if you don’t have determination.
We are
One Team . We only succeed when we work together.
Job Description
The Senior Director, Global Medical Affairs Strategy is a key member of the Medical Affairs leadership team and will function as a scientific and medical expert for Medical Affairs, as well as other groups across the company. This individual will be responsible for developing and executing the overall global medical affairs strategy and tactical plans for the current and future Bicycle portfolio. This role will include overseeing the development of global medical affairs plans and cross-functional integrated evidence plans. This leader will provide strategic input into the Global Product Teams (GPTs), either directly or through oversight of the medical affairs representation on GPTs. The successful candidate will have a successful track record of developing and driving medical strategy for multiple assets, including the effective communication of scientific data through publications, medical communications, scientific engagement, advisory boards, congress activities, and medical information. In addition, the Senior Director will support data generation and life cycle management activities as well as develop relationships with global thought leaders in support of programs. This individual will be an experienced people manager, who will lead the global medical affairs strategy function and effectively collaborate across the company.
Lead the development and execution of annual and long-range global medical affairs strategies and tactics to support the clinical development of the portfolio and prepare for future launch readiness
Develop and execute strategy for the utilization of scientific data generated by preclinical, clinical, and Real-World Evidence (RWE) studies
Establish the Global Medical Affairs Team (GMAT) structure and cadence at Bicycle to develop and execute on medical strategies and tactic
Lead cross-functional GMAT teams directly or through oversight of other medical strategy team members to develop and implement integrated medical strategy for Bicycle products
Ensure medical affairs strategy collaboration and strategic alignment with the field medical affairs team and support scientific communication material development to support KOL engagement
Take accountability for the Investigator-Sponsored Trial (IST) strategy for Bicycle programs and serve as a key individual in the development, roll-out, and operation of IST programs
Provide advice to the Medical, Legal, and Regulatory (MLR) review team and resolve escalations
Assure close but appropriate coordination of medical affairs strategies and activities with clinical development, clinical operations, commercial, translational, research, corporate communications, investor relations, and other key Bicycle stakeholders
Provide strategic oversight and assist as needed, in the development of publications (i.e., abstracts, presentations, manuscripts), integrated evidence plans, lifecycle management plans, congress plans, medical education plans, SOPs, ISTs, budgets, and RWE/HEOR plans\
Present at scientific advisory boards and internal/external meetings
Qualifications
Prior biopharmaceutical industry experience is required (10+ years of experience preferred) in medical affairs and oncology drug development
Advanced degree in health-related field (MD, PhD, or PharmD preferred)
Strong leadership skills with track-record of building and managing effective teams
Ability to think strategically and translate scientific information into medical affairs strategies
Ability to understand complex information and simplify into concise scientific messages
Ability to navigate and succeed in a dynamic, fast-paced environment with a high degree of collaboration and teamwork
Open, engaging, and transparent with ability resolve conflict
Global perspective and mindset with ability work with colleagues and stakeholders from various cultures, backgrounds, and geographies
Strategic thinking with strong business acumen and the ability to prioritize
Excellent communication and presentation skills with the ability to influence key stakeholders
Proficiency in clinical trial data review and interpretation
Knowledge of U.S. and ex-U.S. healthcare systems
Occasional business travel required (~25%)
Additional Information
Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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