Stanford University
Lead Research Scientist, Animal Pharmacology
Stanford University, Palo Alto, California, United States, 94306
SCHOOL/UNIT DESCRIPTION:
Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking discoveries that advance our understanding of and ability to improve human health.
Sarafan ChEM-H has partnered with Stanford Medicine to launch a bold new translational research initiative – Stanford’s Innovative Medicines Accelerator (IMA). IMA aims to accelerate the translation of scientific discoveries at Stanford University into new therapeutics that impact human health while improving our understanding of human biology. The Preclinical pharmacology team works closely with the Medicinal Chemistry, High Throughput Screening and Protein Engineering modules. They propel IMA projects with quantitative measurements of drug candidates that guide medicinal chemists and protein engineers toward drug prototypes. Preclinical pharmacology collects information about how drug candidates interact with their targets, affect cells in culture and behave in animals. Preclinical pharmacology informs how drug candidates will behave in humans.
POSITION SUMMARY:
The Stanford Innovative Medicines Accelerator (IMA) is seeking a dedicated Lead Research Scientist, Animal Pharmacology to support IMA’s portfolio of drug discovery projects. Reporting to the Director of Pre-clinical Pharmacology, you will lead complex in vivo studies across various therapeutic modalities, collaborating with scientific teams to refine strategies that align with IMA’s preclinical goals. You have extensive experience utilizing transgenic mouse models to design and execute pharmacokinetic and pharmacodynamic studies, as well as GLP toxicity assessments. Familiarity with institutional requirements for animal use and welfare in pharmacology experiments is essential. Additionally, you will effectively communicate the goals, protocols, and results, contribute to regulatory submissions, and foster cross-team collaboration to enhance IMA's research innovation and decision-making processes.
CORE DUTIES:
Support complex scientific and research; analyze data, monitor and oversee experimental process, and design and develop prototypes, specialized equipment, and/or systems.
Collaborate with scientists, engineers, or senior administrative officers to oversee complex non-routine analyses, select optimum solutions, design and develop special purpose equipment and/or systems, and perform corrective modifications to equipment and system designs.
Contribute to or may have lead responsibility for the planning, design, and implementation of scientific or engineering initiatives, and work toward project objective.
Oversee and make decisions independently for operation, maintenance, and development of laboratory space.
Oversee and prepare periodic financial and technical reports and operating plans.
Clarify and resolve complex technical issues with substantial significance and impact, which may span multiple areas, using advanced technical and professional knowledge.
Serve as a resource in review of research proposals and research capabilities and make recommendations.
Establish, communicate, and enforce compliance with health and safety policies and procedures.
Oversee development of training manuals and safety guidelines, and train new instrumentation users, researchers, and/or technical staff.
Perform supervisory duties, including hiring, performance management, and related duties, overseeing the work of technicians and other staff associated with the group/project, supervising the installation, maintenance, troubleshooting, and operation of complex scientific or engineering projects, and training technicians, operators, and others working in a particular scientific or engineering function area.
MINIMUM REQUIREMENTS:
Education & Experience:
Bachelor’s degree in engineering, science, or related field and six years of relevant experience; or a combination of education and relevant experience.
Knowledge, Skills and Abilities:
Demonstrated knowledge and skills of advanced scientific or engineering principles and practices.
Extensive experience applying complex scientific and engineering principles and performing special technical services and the ability to articulate and translate implementation requirements to the planning, design, development, operations, and performance of complex equipment and systems.
In-depth experience using software applications, systems, or programs relevant for the job.
Ability to supervise others in oversight and management of instrumentation or system installation.
Demonstrated ability to oversee, maintain, and develop a laboratory space including demonstrated ability to and supervise the work of technicians and other staff associated with the group.
Demonstrated ability to critically review research proposals, prepare reports, evaluate research capabilities, and make recommendations.
Demonstrated ability to establish, communicate, and enforce compliance with health and safety policies and procedures.
Proven ability to establish, communicate, and enforce animal ethics and safety policies and procedures effectively.
Demonstrated ability to effectively supervise and train a diverse work staff.
Preferred background and qualifications:
Ph.D. in Pharmacology or Pharmaceutical Sciences, complemented by relevant postgraduate experience.
8+ years of industry experience in in vivo pharmacology and toxicology, knowledge of regulatory guidelines is a plus.
Experienced in working with GEMM and humanized mouse models.
Extensive hands-on experience conducting vivo studies, including administering test molecules, euthanizing animals, and collecting organs and blood samples for further analysis, and histology.
Extensive experience in identifying animal models for designing, executing and managing in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies across multiple CROs.
Experienced in working with multiple therapeutic modalities including small molecules and large molecules.
A strong record of achievement, including publications.
Proficient in writing animal ethics protocols and ensuring compliance with regulations.
Experience managing direct reports, overseeing in vivo strategy, setting project priorities, and optimizing resource allocation.
PHYSICAL REQUIREMENTS*:
Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh >40 pounds.
- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job.
WORKING CONDITIONS:
May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.
May require travel.
WORK STANDARDS:
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu.
For On-site or Hybrid positions:
The expected pay range for this position is $120,737 to $150,199 per annum.
Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on a wide range of factors that are unique to each candidate including but not limited to geographic location, knowledge, skills and abilities, relevant education, depth and breadth of experience, performance; as well as other business and organization needs such as (but not limited to) the scope and responsibilities of the position, the minimum qualifications, departmental budget availability, and market and internal equity across the unit, department and reporting relationships.
At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.
Why Stanford is for You
Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:
Freedom to grow.
We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.
A caring culture.
We provide superb retirement plans, generous time-off, and family care resources.
A healthier you.
Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.
Discovery and fun.
Stroll through historic sculptures, trails, and museums.
Enviable resources.
Enjoy free commuter programs, ridesharing incentives, discounts and more!
The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.
Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting a
contact form
.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
#J-18808-Ljbffr
Sarafan ChEM-H is an interdisciplinary institute focused on connecting Chemistry, Engineering, and Medicine for Human Health. The institute was founded as a joint venture of the Schools of Medicine, Engineering, and Humanities and Sciences. The proximity of world-class biologists, chemists, engineers, and clinicians at Stanford presents a unique opportunity to study human biology at a molecular level, to translate this knowledge into groundbreaking discoveries that advance our understanding of and ability to improve human health.
Sarafan ChEM-H has partnered with Stanford Medicine to launch a bold new translational research initiative – Stanford’s Innovative Medicines Accelerator (IMA). IMA aims to accelerate the translation of scientific discoveries at Stanford University into new therapeutics that impact human health while improving our understanding of human biology. The Preclinical pharmacology team works closely with the Medicinal Chemistry, High Throughput Screening and Protein Engineering modules. They propel IMA projects with quantitative measurements of drug candidates that guide medicinal chemists and protein engineers toward drug prototypes. Preclinical pharmacology collects information about how drug candidates interact with their targets, affect cells in culture and behave in animals. Preclinical pharmacology informs how drug candidates will behave in humans.
POSITION SUMMARY:
The Stanford Innovative Medicines Accelerator (IMA) is seeking a dedicated Lead Research Scientist, Animal Pharmacology to support IMA’s portfolio of drug discovery projects. Reporting to the Director of Pre-clinical Pharmacology, you will lead complex in vivo studies across various therapeutic modalities, collaborating with scientific teams to refine strategies that align with IMA’s preclinical goals. You have extensive experience utilizing transgenic mouse models to design and execute pharmacokinetic and pharmacodynamic studies, as well as GLP toxicity assessments. Familiarity with institutional requirements for animal use and welfare in pharmacology experiments is essential. Additionally, you will effectively communicate the goals, protocols, and results, contribute to regulatory submissions, and foster cross-team collaboration to enhance IMA's research innovation and decision-making processes.
CORE DUTIES:
Support complex scientific and research; analyze data, monitor and oversee experimental process, and design and develop prototypes, specialized equipment, and/or systems.
Collaborate with scientists, engineers, or senior administrative officers to oversee complex non-routine analyses, select optimum solutions, design and develop special purpose equipment and/or systems, and perform corrective modifications to equipment and system designs.
Contribute to or may have lead responsibility for the planning, design, and implementation of scientific or engineering initiatives, and work toward project objective.
Oversee and make decisions independently for operation, maintenance, and development of laboratory space.
Oversee and prepare periodic financial and technical reports and operating plans.
Clarify and resolve complex technical issues with substantial significance and impact, which may span multiple areas, using advanced technical and professional knowledge.
Serve as a resource in review of research proposals and research capabilities and make recommendations.
Establish, communicate, and enforce compliance with health and safety policies and procedures.
Oversee development of training manuals and safety guidelines, and train new instrumentation users, researchers, and/or technical staff.
Perform supervisory duties, including hiring, performance management, and related duties, overseeing the work of technicians and other staff associated with the group/project, supervising the installation, maintenance, troubleshooting, and operation of complex scientific or engineering projects, and training technicians, operators, and others working in a particular scientific or engineering function area.
MINIMUM REQUIREMENTS:
Education & Experience:
Bachelor’s degree in engineering, science, or related field and six years of relevant experience; or a combination of education and relevant experience.
Knowledge, Skills and Abilities:
Demonstrated knowledge and skills of advanced scientific or engineering principles and practices.
Extensive experience applying complex scientific and engineering principles and performing special technical services and the ability to articulate and translate implementation requirements to the planning, design, development, operations, and performance of complex equipment and systems.
In-depth experience using software applications, systems, or programs relevant for the job.
Ability to supervise others in oversight and management of instrumentation or system installation.
Demonstrated ability to oversee, maintain, and develop a laboratory space including demonstrated ability to and supervise the work of technicians and other staff associated with the group.
Demonstrated ability to critically review research proposals, prepare reports, evaluate research capabilities, and make recommendations.
Demonstrated ability to establish, communicate, and enforce compliance with health and safety policies and procedures.
Proven ability to establish, communicate, and enforce animal ethics and safety policies and procedures effectively.
Demonstrated ability to effectively supervise and train a diverse work staff.
Preferred background and qualifications:
Ph.D. in Pharmacology or Pharmaceutical Sciences, complemented by relevant postgraduate experience.
8+ years of industry experience in in vivo pharmacology and toxicology, knowledge of regulatory guidelines is a plus.
Experienced in working with GEMM and humanized mouse models.
Extensive hands-on experience conducting vivo studies, including administering test molecules, euthanizing animals, and collecting organs and blood samples for further analysis, and histology.
Extensive experience in identifying animal models for designing, executing and managing in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies across multiple CROs.
Experienced in working with multiple therapeutic modalities including small molecules and large molecules.
A strong record of achievement, including publications.
Proficient in writing animal ethics protocols and ensuring compliance with regulations.
Experience managing direct reports, overseeing in vivo strategy, setting project priorities, and optimizing resource allocation.
PHYSICAL REQUIREMENTS*:
Frequently grasp lightly/fine manipulation, perform desk-based computer tasks, lift/carry/push/pull objects that weigh up to 10 pounds.
Occasionally stand/walk, sit, twist/bend/stoop/squat, grasp forcefully.
Rarely kneel/crawl, climb (ladders, scaffolds, or other), reach/work above shoulders, use a telephone, writing by hand, sort/file paperwork or parts, operate foot and/or hand controls, lift/carry/push/pull objects that weigh >40 pounds.
- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of the job.
WORKING CONDITIONS:
May be exposed to high voltage electricity, radiation or electromagnetic fields, lasers, noise > 80dB TWA, Allergens/Biohazards/Chemicals /Asbestos, confined spaces, working at heights ?10 feet, temperature extremes, heavy metals, unusual work hours or routine overtime and/or inclement weather.
May require travel.
WORK STANDARDS:
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu.
For On-site or Hybrid positions:
The expected pay range for this position is $120,737 to $150,199 per annum.
Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on a wide range of factors that are unique to each candidate including but not limited to geographic location, knowledge, skills and abilities, relevant education, depth and breadth of experience, performance; as well as other business and organization needs such as (but not limited to) the scope and responsibilities of the position, the minimum qualifications, departmental budget availability, and market and internal equity across the unit, department and reporting relationships.
At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.
Why Stanford is for You
Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks empower you with:
Freedom to grow.
We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.
A caring culture.
We provide superb retirement plans, generous time-off, and family care resources.
A healthier you.
Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.
Discovery and fun.
Stroll through historic sculptures, trails, and museums.
Enviable resources.
Enjoy free commuter programs, ridesharing incentives, discounts and more!
The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned.
Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting a
contact form
.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
#J-18808-Ljbffr