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Vedanta Biosciences, Inc.

Scientist I/II, Bioinformatics

Vedanta Biosciences, Inc., Cambridge, Massachusetts, us, 02140


We believe that in the near future, doctors will have an entirely new option to treat patients: bacterial consortia therapeutics. We are enabling this new drug class with groundbreaking and industry-leading scientific work powered by large-scale capabilities to identify, screen, and manufacture bacteria with drug-like properties. Our team is at the core of all we do - and we're excited to meet new team members!About Us, About You

At Vedanta, we value diversity in all its forms and are looking for candidates with a wide variety of perspectives, backgrounds, education, and experiences. We believe that a diverse and inclusive workforce builds the strongest team possible.

We're proud of our workplace culture. Our Vedanta Values inspire us to be the best professionals and colleagues possible. Our values are:Respect - Collaboration - Execution - Effective Communication - Problem Solving - Scientific ThoroughnessLocation and Reporting

Location: Cambridge, MA, hybrid, or remoteReports to: Senior Director, Systems BiologyAbout Vedanta Biosciences

Vedanta Biosciences is a late-stage biopharmaceutical company developing medicines for the treatment of gastrointestinal diseases. The company’s lead assets include potential first-in-class oral therapies, VE303, a Phase 3-ready candidate for recurrent

C. difficile

infection, and VE202, in a Phase 2 trial for ulcerative colitis. Vedanta’s pipeline has been built using the company’s industry-leading product engine for the development of therapies based on defined consortia of bacteria grown from pure clonal cell banks.The Role

We are looking for a bioinformatician/computational biologist to join the Research and Development team to support the development of Vedanta Biosciences’ portfolio of Live Biotherapeutic Products (LBPs). The candidate will lead the execution of existing microbiome analysis and bacterial genomics workflows, conduct benchmarking studies to evaluate these workflows and new approaches, and design, test, and implement bioinformatic process improvements. The candidate will lead the characterization of bacterial isolate genomes, develop tools for predicting strain function or growth potential from genomic content, curate Vedanta’s growing database of cultured isolates, and support pre-clinical and clinical microbiome analyses.Here’s What You’ll Do

Lead the execution of bioinformatic workflows for processing and characterization of bacterial strain genomes and stool metagenomes.Conceptualize and establish novel bioinformatic microbiome analysis workflows in support of pre-clinical and clinical programs.Curate Vedanta’s collection of bacterial genomes and build reference genome databases.Develop bioinformatic methods for studying bacterial strain colonization and predicting bacterial strain function or growth potential from genomic content.Work with long- and short-read sequencing technologies to assemble and annotate bacterial isolate genomes.Develop and apply algorithms for taxonomic clustering and classification in complex microbial communities.Requirements

MS/PhD in bioinformatics, computational biology, or related quantitative field with 3+ years of working experience.3+ years of experience in a scripting language, such as Rust, Perl, or Python.1+ years of working experience in the development and operation of reproducible bioinformatic pipelines (i.e. Nextflow, Snakemake) is highly desirable.Analytical experience with metagenomic and hybrid bacterial genome assembly, binning, annotation, and taxonomic identification (e.g. MEGAHIT, metaSPAdes, UniCycler) is required.Analytical experience with microbiome and microbial community ecology datasets is required.Experience with assembly-independent strain characterization tools (e.g. StrainPhlAn, PanPhlAn) is highly desirable.Experience with cloud computing infrastructure (i.e. AWS, Google Cloud) and version control (i.e. git) are highly desirable.Experience with software standardization (e.g. Docker, BioContainer) and relational database development (e.g. SQL, MySQL, RDS) are desirable.Highly organized and motivated individual. Detail-oriented. Must be a team player, able to work well in a group setting as well as independently in a fast-paced environment.Our Vision

Pioneering microbiome therapeutics by using Defined Bacterial Consortia to transform the lives of patients with serious diseases.Vedanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Vedanta will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Vedanta Biosciences requires all employees to be fully vaccinated against COVID-19 and newly hired employees must be fully vaccinated prior to their employment start date. Vedanta Biosciences will consider accommodations for individuals who are unable to be vaccinated against COVID-19 due to a qualifying medical condition or disability or a sincerely held religious objection.Apply for this job

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