Atlas Venture
Associate Director / Director, Biotherapeutics Engineering
Atlas Venture, Waltham, Massachusetts, United States, 02254
Associate Director / Director, Biotherapeutics Engineering
Company Address:
828 Winter St, Waltham, Massachusetts 02451, USAbout Xilio Therapeutics
Focused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.Job Description
Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment.SUMMARY:We are seeking a highly skilled and experienced Associate Director or Director in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise as well as innovative computational methods. The successful candidate will have a strong background in structural biology, protein engineering, and antibody discovery workflows. A solid background in applying machine learning techniques and molecular modeling to improve the biophysical and biological properties of biotherapeutics is highly desired. The candidate is expected to have expertise in leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC). If the successful candidate has management experience and continued interest in people management, the role may be offered as Associate Director, overseeing three direct reports.Job Responsibilities:Manages a team of scientists in biologic therapeutic engineering and platform development activities, ensuring deliverables within timelines.Represents the group as project team representative and communicates project-related needs to the Biotherapeutic Engineering (BE) group.Serves as a subject matter expert in BE, including protein engineering, sequence identification, and innovative biologic designs.Applies state-of-the-art in silico biotherapeutic engineering tools to design and optimize biologics-based drugs.Utilizes cutting-edge generative AI, machine learning, and molecular modeling techniques to enhance the properties of biologics-based drugs.Leads or co-leads research project teams, accountable for defining project strategy and ensuring effective execution of activities.Represents Protein Engineering at project team meetings.Supports writing and reporting of key experiments in IND filings.Captures detailed experimental information in electronic lab notebook (ELN) entries.Skills, Qualifications, and Requirements:PhD in Structural Biology, Chemical and Biomolecular Engineering or a related field and a minimum of 7-9 years of relevant post-graduate experience in industry or academic setting.Experience leading a committed team of scientists and communicating timelines and priorities, including CRO project management.Strong expertise in biotherapeutics engineering, focusing on antibody-based therapeutics and computational methods for drug design and optimization.Expertise in protein design, humanization, and bioinformatics, including molecular modeling using in silico tools.Strong analytical and problem-solving skills for computational analysis of protein, DNA, and mRNA sequences.Demonstrated experience in applying machine learning techniques to improve properties of biologics-based drugs.Knowledge of generative AI/machine learning algorithms and experience in data mining using APIs.Experience in cloud computing and/or coding (SQL, R, python) for data analytics.Familiarity with antibody discovery methodologies is highly desired.Proven track record of leading cross-functional teams and successfully delivering projects from in silico concepts to in vivo proof of concept.Excellent leadership and communication skills to effectively lead cross-functional teams and collaborate with stakeholders.Diversity, Equity and InclusionAt Xilio Therapeutics, we foster a culture of equity, diversity, and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.
#J-18808-Ljbffr
Company Address:
828 Winter St, Waltham, Massachusetts 02451, USAbout Xilio Therapeutics
Focused on harnessing the immune system to achieve deep and durable clinical responses to improve the lives of patients.Job Description
Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment.SUMMARY:We are seeking a highly skilled and experienced Associate Director or Director in Biotherapeutics Engineering to design and optimize biologics-based drugs, incorporating structural biology expertise as well as innovative computational methods. The successful candidate will have a strong background in structural biology, protein engineering, and antibody discovery workflows. A solid background in applying machine learning techniques and molecular modeling to improve the biophysical and biological properties of biotherapeutics is highly desired. The candidate is expected to have expertise in leading cross-functional teams, generating key data, and driving projects from in silico concepts to in vivo proof of concept (PoC). If the successful candidate has management experience and continued interest in people management, the role may be offered as Associate Director, overseeing three direct reports.Job Responsibilities:Manages a team of scientists in biologic therapeutic engineering and platform development activities, ensuring deliverables within timelines.Represents the group as project team representative and communicates project-related needs to the Biotherapeutic Engineering (BE) group.Serves as a subject matter expert in BE, including protein engineering, sequence identification, and innovative biologic designs.Applies state-of-the-art in silico biotherapeutic engineering tools to design and optimize biologics-based drugs.Utilizes cutting-edge generative AI, machine learning, and molecular modeling techniques to enhance the properties of biologics-based drugs.Leads or co-leads research project teams, accountable for defining project strategy and ensuring effective execution of activities.Represents Protein Engineering at project team meetings.Supports writing and reporting of key experiments in IND filings.Captures detailed experimental information in electronic lab notebook (ELN) entries.Skills, Qualifications, and Requirements:PhD in Structural Biology, Chemical and Biomolecular Engineering or a related field and a minimum of 7-9 years of relevant post-graduate experience in industry or academic setting.Experience leading a committed team of scientists and communicating timelines and priorities, including CRO project management.Strong expertise in biotherapeutics engineering, focusing on antibody-based therapeutics and computational methods for drug design and optimization.Expertise in protein design, humanization, and bioinformatics, including molecular modeling using in silico tools.Strong analytical and problem-solving skills for computational analysis of protein, DNA, and mRNA sequences.Demonstrated experience in applying machine learning techniques to improve properties of biologics-based drugs.Knowledge of generative AI/machine learning algorithms and experience in data mining using APIs.Experience in cloud computing and/or coding (SQL, R, python) for data analytics.Familiarity with antibody discovery methodologies is highly desired.Proven track record of leading cross-functional teams and successfully delivering projects from in silico concepts to in vivo proof of concept.Excellent leadership and communication skills to effectively lead cross-functional teams and collaborate with stakeholders.Diversity, Equity and InclusionAt Xilio Therapeutics, we foster a culture of equity, diversity, and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.
#J-18808-Ljbffr