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Neurocrine Biosciences

TEMP - Scientist, Analytical Chem Research

Neurocrine Biosciences, San Diego, California, United States, 92189


Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do: Neurocrine Biosciences is a neuroscience-focused biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. About the Role: Responsible for assigned small molecule purification and analysis studies, in support of discovery programs at Neurocrine Biosciences Inc. using, but not limited to, HPLC and SFC chromatography, method development/optimization, achiral and chiral small molecule analysis and purification, and instrument maintenance/troubleshooting. Your Contributions (include, but are not limited to): Performs daily achiral small molecule analyses and purifications in a high throughput setting utilizing both LC and SFC instrumentation. Executes and/or optimizes HPLC/SFC methods for achiral/chiral small molecules; supports the development of chiral and achiral methodologies to purify small molecules using mass-directed HPLC and SFC technology. Performs routine instrument maintenance, repair and may troubleshoot complex instrument issues. Operates liquid handling robotics. Uses sample data to develop preliminary analysis and findings. Supports the development of presentations of laboratory studies/analysis and findings. Regularly sets up laboratory for new and/or continued purification and analysis. Other duties as assigned. Requirements: Bachelor's degree in Chemistry, Biochemistry or similar discipline and 2+ years of experience in pharmaceutical industry, specifically small molecule purification and analysis. Hands-on experiences with HPLC/SFC Chromatography and liquid robotics preferred. Experience with analytical method development and preparative chromatography for small molecule chiral and achiral pharmaceutical compounds. Experience in instrument maintenance and troubleshooting preferred OR MS degree in Chemistry, Biochemistry or similar discipline and some industry experience as noted above OR PhD degree in Chemistry, Biochemistry or similar discipline and some industry or relevant experience a plus. Ability to identify complex problems and solve routine problems. Ability to work under various timelines, while maintaining quality of work. Working knowledge of HPLC/SFC chromatography. Analytical and preparative focus with this technology is required. Continuous drive to increase lab productivity and throughput through scientific creativity. Recognizes fundamental anomalies in data points and identifies issues in experiments/processes. Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals. Strong knowledge of one scientific discipline. Good knowledge of scientific principles, methods and techniques. Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools. Ability to work as part of a team; Strong computer skills. Good problem-solving, analytical thinking skills. Detail oriented. Ability to meet deadlines. Good project management skills. Strong communication skills, ability to work independently, and creative approaches to problem solve, are essential in performing daily tasks and responsibilities.

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