Postdoctoral Researcher, Computational Chemistry

DescriptionNote: this is an onsite position starting in January 2025. The application window is open until November 4, 2024.Company Overview:Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.Vividion was ranked #2 mid-size company on The San Diego Union-Tribune's 2022 and 2023 Top Workplaces list.Job Summary:The successful candidate will be responsible for developing and applying computational methods, workflows and analyses for finding protein cryptic pockets. This research is in collaboration with Bayer Crop Science and Bayer Pharmaceuticals.RequirementsEducation and Experience requirements:Ph.D. in computational chemistry, molecular modeling or related fieldsA record of research success through publications.Expertise in molecular dynamics software (AMBER, CHARMM, GROMACS, NAMD, DESMOND, etc.)Expertise in protein conformational analysis.Experience programming or scripting (C++ and/or Python experience preferred)Essential Duties and Responsibilities:Develop computational methods for cryptic pocket detection.Apply CADD techniques for virtual ligand screening.Report and present work to internal team and Bayer collaborators.Present findings to scientific community.Pay & Benefits:The expected compensation for this position is between $75,000 to $85,000 per year commensurate with experience.EEO & Employment Eligibility:Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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