Senior Scientist - Protein Engineering

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services, and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody-drug conjugates, and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists embedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease-modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We are seeking an enthusiastic, creative, and versatile Senior Scientist to join our collaborative Protein Engineering team to drive technological innovation, discover and engineer innovative biotherapeutic candidates. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems, develop new skills, and use them to implement robust platforms for protein therapeutic optimization. You will collaborate with talented colleagues and share what you learn. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents.

Responsibilities

Drive efforts to engineer antibodies, multispecifics, and alternative biologics formats for optimal therapeutic performanceSelections on yeast display libraries, routine operation and maintenance of a sorterLibrary design in collaboration with AI/ML engineers, library construction, NGSIndependently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROsAnalyze library NGS data using no-code or low-code bioinformatics platformsIndependently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practicesPresent results internally and externally, attend industry conferencesAccomplish goals under project team timelinesBasic Qualifications

Bachelor's Degree with 7+ years of academic or industry experienceOR

Master's Degree with 5+ years of academic or industry experienceOR

PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 2+ years of academic or industry experiencePreferred Qualifications

PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 2+ years of relevant post-graduate or biotech/biopharma industry experienceExperience with molecular and microbiology techniques underlying yeast display workIn-depth understanding and experience in antibody engineering is highly desirableDemonstrated experience in working in a cross-functional organization is requiredExperience in lead discovery and optimization is preferredFundamental understanding of proteins, antibodies, and structure-function relationships required. Familiarity with protein structure analysis (Pymol, Chimera, MOE).DNA and RNA purification, cloning, PCR, Sanger sequencing, NGS library preparationFlow cytometry and FACSFamiliarity with protein-protein interaction techniques and kinetics (BLI, SPR, on-cell binding)Bioinformatics or data science experience is desirable (bash, Python, or R)Proficiency with Microsoft Office suite, FlowJo, Prism, DNA cloning softwareExcellent written and oral communication skillsThe starting compensation for this job is a range from $109,000 - $150,700 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.#J-18808-Ljbffr