GlaxoSmithKline
Principal Scientist
GlaxoSmithKline, Collegeville, Pennsylvania, United States, 19426
Site Name:
USA - Pennsylvania - Upper ProvidencePosted Date:
Nov 5 2024GSK is currently looking for a Principal Scientist to join our team in Upper Providence, PA. This role is for a scientist responsible for delivering key non-clinical safety data both in traditional clinical pathology sciences as well as immune-safety for projects across the R&D portfolio. You will be an integral part of a high performing team that measures biomarkers for target-organ toxicity and adverse immune effects on nonclinical studies. You will contribute to the interpretation of the clinical relevance of your data as it supports safe progression of clinical candidates in patients. In this role you may perform the following job-related activities; together with other appropriate tasks, as requested by management:Key Responsibilities and AccountabilitiesFocus of the job will cover both clinical pathology and immune-related biomarkers.Provide subject matter and technical expertise on relevant study endpoints.Perform testing/data analysis and interpretation related to clinical pathology laboratory analyses: hematology, clinical chemistry, coagulation, urinalysis, immunoassay-based biomarkers, blood smear, bone marrow smear and other relevant diagnostic capabilities to monitor animal health.Perform testing/data analysis and interpretation related to immune profiling: high dimensional flow cytometry, targeted transcriptomics, multiplex immunoassays and bioassays.Work cooperatively in a team that coordinates multiple simultaneous study activities.Responsible for generation of data tables/figures and written draft summaries of findings to support the reporting of study results. Ensure timely communication to the Study Director/Investigator of study related events and/or deviations.Support automation of laboratory workflows.Ensure scientific data integrity for accuracy and quality.Conduct work in accordance with study protocols, Standard Operating Procedures (SOPs), and GSK policies.Why you?
Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:BS/MS in Clinical Laboratory Sciences/Medical Technology AND 5+ years of nonclinical/clinical laboratory and/or pharmaceutical industry experienceORPhD in Immunology or Related Degree (e.g., Biomedical Research, Biology, or Cellular and Molecular biology)Preferred Qualifications:If you have the following characteristics, it would be a plus:Education with a focus on Immunology and/or ToxicologyHands-on experience in multiple clinical pathology laboratory areas including hematology, clinical chemistry, and other relevant capabilities.Hands-on experience in profiling immune biomarkers with state-of-the-art technologies (e.g., high dimensional flow cytometry, targeted transcriptomics, multiplex immunoassays and bioassays).Demonstrable experience in scientific critical thinking and independent planning, design and execution of experiments to test hypotheses.Proficiency in automated workflows.Experienced with compilation, analysis, visualization and interpretation of complex datasets.ASCP certificationExperience with troubleshooting and resolving technical issues related to experimental processes or complex laboratory instrumentation.Demonstrable timely delivery of scientific data that meets acceptable data integrity standards.Experience in working closely with multidisciplinary teams and collaborating across organizational boundaries.
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USA - Pennsylvania - Upper ProvidencePosted Date:
Nov 5 2024GSK is currently looking for a Principal Scientist to join our team in Upper Providence, PA. This role is for a scientist responsible for delivering key non-clinical safety data both in traditional clinical pathology sciences as well as immune-safety for projects across the R&D portfolio. You will be an integral part of a high performing team that measures biomarkers for target-organ toxicity and adverse immune effects on nonclinical studies. You will contribute to the interpretation of the clinical relevance of your data as it supports safe progression of clinical candidates in patients. In this role you may perform the following job-related activities; together with other appropriate tasks, as requested by management:Key Responsibilities and AccountabilitiesFocus of the job will cover both clinical pathology and immune-related biomarkers.Provide subject matter and technical expertise on relevant study endpoints.Perform testing/data analysis and interpretation related to clinical pathology laboratory analyses: hematology, clinical chemistry, coagulation, urinalysis, immunoassay-based biomarkers, blood smear, bone marrow smear and other relevant diagnostic capabilities to monitor animal health.Perform testing/data analysis and interpretation related to immune profiling: high dimensional flow cytometry, targeted transcriptomics, multiplex immunoassays and bioassays.Work cooperatively in a team that coordinates multiple simultaneous study activities.Responsible for generation of data tables/figures and written draft summaries of findings to support the reporting of study results. Ensure timely communication to the Study Director/Investigator of study related events and/or deviations.Support automation of laboratory workflows.Ensure scientific data integrity for accuracy and quality.Conduct work in accordance with study protocols, Standard Operating Procedures (SOPs), and GSK policies.Why you?
Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:BS/MS in Clinical Laboratory Sciences/Medical Technology AND 5+ years of nonclinical/clinical laboratory and/or pharmaceutical industry experienceORPhD in Immunology or Related Degree (e.g., Biomedical Research, Biology, or Cellular and Molecular biology)Preferred Qualifications:If you have the following characteristics, it would be a plus:Education with a focus on Immunology and/or ToxicologyHands-on experience in multiple clinical pathology laboratory areas including hematology, clinical chemistry, and other relevant capabilities.Hands-on experience in profiling immune biomarkers with state-of-the-art technologies (e.g., high dimensional flow cytometry, targeted transcriptomics, multiplex immunoassays and bioassays).Demonstrable experience in scientific critical thinking and independent planning, design and execution of experiments to test hypotheses.Proficiency in automated workflows.Experienced with compilation, analysis, visualization and interpretation of complex datasets.ASCP certificationExperience with troubleshooting and resolving technical issues related to experimental processes or complex laboratory instrumentation.Demonstrable timely delivery of scientific data that meets acceptable data integrity standards.Experience in working closely with multidisciplinary teams and collaborating across organizational boundaries.
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