Denali Therapeutics
Principal Scientist - Toxicology
Denali Therapeutics, South San Francisco, California, us, 94083
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
Principal Scientist, Toxicology
The Principal Scientist, Toxicology will play a critical role in supporting the nonclinical safety assessment of small and large molecule therapeutics within Denali’s pipeline. This position involves conducting and managing toxicology studies, analyzing and interpreting safety data, and collaborating with cross-functional teams to advance drug candidates through various stages of development.
Key Accountabilities/Core Job Responsibilities:
Nonclinical Toxicology Support:
Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates.
Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards.
Data Analysis and Reporting:
Analyze, interpret, and summarize toxicology data to support safety evaluations.
Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making.
Regulatory Support:
Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments.
Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies.
Collaboration and Cross-Functional Work:
Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams.
Participate in project meetings, offering insights and recommendations to advance safety assessment strategies.
Investigative Efforts:
Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates.
Assist in developing and implementing de-risking strategies for drug discovery and development projects.
Qualifications/Skills:
PhD in Toxicology, Biology, Pharmacology or related scientific discipline
10+ years of biotech/pharmaceutical drug discovery/development experience
Experience with biologics and oligonucleotides preferred
Strong scientific background and scientific aptitude
Excellent critical thinking and scientific skills
Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
Ability to work in a fast-paced environment
Excellent oral, presentation, and written communication skills
Salary Range:
$200,000.00 to $227,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
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We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
Principal Scientist, Toxicology
The Principal Scientist, Toxicology will play a critical role in supporting the nonclinical safety assessment of small and large molecule therapeutics within Denali’s pipeline. This position involves conducting and managing toxicology studies, analyzing and interpreting safety data, and collaborating with cross-functional teams to advance drug candidates through various stages of development.
Key Accountabilities/Core Job Responsibilities:
Nonclinical Toxicology Support:
Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates.
Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards.
Data Analysis and Reporting:
Analyze, interpret, and summarize toxicology data to support safety evaluations.
Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making.
Regulatory Support:
Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments.
Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies.
Collaboration and Cross-Functional Work:
Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams.
Participate in project meetings, offering insights and recommendations to advance safety assessment strategies.
Investigative Efforts:
Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates.
Assist in developing and implementing de-risking strategies for drug discovery and development projects.
Qualifications/Skills:
PhD in Toxicology, Biology, Pharmacology or related scientific discipline
10+ years of biotech/pharmaceutical drug discovery/development experience
Experience with biologics and oligonucleotides preferred
Strong scientific background and scientific aptitude
Excellent critical thinking and scientific skills
Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
Ability to work in a fast-paced environment
Excellent oral, presentation, and written communication skills
Salary Range:
$200,000.00 to $227,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
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