Janux Therapeutics
Principal/Senior Principal Scientist, Immunoassays
Janux Therapeutics, San Diego, California, United States, 92189
As a member of the pharmacology group, we seek a scientifically curious and motivated Principal or Senior Principal Scientist with an ability to work in a fast-paced environment. The incumbent will develop and execute the Immunoassay method development to support nonclinical and clinical sample analysis, as well as assay transfer to CRO and study monitoring.This position is hands-on and requires the effective study execution, communication, and documentation of results that enable the advancement of prototype method to fully validated assays. Strong candidates will be creative, collaborative, and passionate about drug discovery and assay development. Expertise in immunoassays (e.g. ADA and NAb assays) and immunology are required. As a strategic team member, they directly support decision-making for pipeline programs as they progress from early research through an IND and into the clinic. This position will report directly to the Director of In-Vivo Pharmacology.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
Identify, develop and execute immunoassays to support both preclinical and clinical studies.Independently design and execute ADA and NAb assay from assay development, qualification, sample analysis, data analysis, report and SOP drafting.Be responsible for the assay transfer to CROs, and manage associated CRO activities for immunoassays.Provide input on technical inquiries and lead troubleshooting of immunoassays.Analyze and present experimental data using Prism, Excel, MS Office or similar software, and present findings to cross-functional groups.Train and support junior team members to manage and execute complex experimental testing.Produce detailed documentation of experiments within a lab notebook and electronically.Schedule and prioritize workload effectively within a fast-paced environment.Other duties as assigned.
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES
Ph.D. in Biology, Immunology, Cell Biology, Biotechnology, or a related discipline + at least 5 years of assay development experience, MS + 10 years of assay development experience, or BS + 12 years of assay development experience in a biotechnology setting is required.Extensive experience in ADA and NAb assay development and assay validation.Large molecule/Biologic modality experience is a must for this position.Strong understanding and prior experience working in GxP environment is preferred.Experience with Ligand bind based PK assay development is a plus.Hands-on expertise with standard lab techniques such as ELISA, MSD and cell-based assays are required.Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.Competence in data analysis tools (Excel, GraphPad).Strong analytical and critical thinking skills with the ability to work in a fast-paced environment.Excellent written and oral communication skills.
$145,000 - $200,000 a year
In addition to a competitive base salary ranging from $145,000 to $200,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.
Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.Job Type:
Full-timeBenefits:401KMedical insuranceDental insuranceVision insuranceSupplemental disability insurance plansFlexible scheduleLife insuranceFlexible vacationSick timeIncentive stock option planRelocation assistanceSchedule:Monday to FridayWork authorization:United States (Required)Additional Compensation:Annual targeted bonus X%Work Location:On site (San Diego, CA)EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
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ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
Identify, develop and execute immunoassays to support both preclinical and clinical studies.Independently design and execute ADA and NAb assay from assay development, qualification, sample analysis, data analysis, report and SOP drafting.Be responsible for the assay transfer to CROs, and manage associated CRO activities for immunoassays.Provide input on technical inquiries and lead troubleshooting of immunoassays.Analyze and present experimental data using Prism, Excel, MS Office or similar software, and present findings to cross-functional groups.Train and support junior team members to manage and execute complex experimental testing.Produce detailed documentation of experiments within a lab notebook and electronically.Schedule and prioritize workload effectively within a fast-paced environment.Other duties as assigned.
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES
Ph.D. in Biology, Immunology, Cell Biology, Biotechnology, or a related discipline + at least 5 years of assay development experience, MS + 10 years of assay development experience, or BS + 12 years of assay development experience in a biotechnology setting is required.Extensive experience in ADA and NAb assay development and assay validation.Large molecule/Biologic modality experience is a must for this position.Strong understanding and prior experience working in GxP environment is preferred.Experience with Ligand bind based PK assay development is a plus.Hands-on expertise with standard lab techniques such as ELISA, MSD and cell-based assays are required.Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.Competence in data analysis tools (Excel, GraphPad).Strong analytical and critical thinking skills with the ability to work in a fast-paced environment.Excellent written and oral communication skills.
$145,000 - $200,000 a year
In addition to a competitive base salary ranging from $145,000 to $200,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.
Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.Job Type:
Full-timeBenefits:401KMedical insuranceDental insuranceVision insuranceSupplemental disability insurance plansFlexible scheduleLife insuranceFlexible vacationSick timeIncentive stock option planRelocation assistanceSchedule:Monday to FridayWork authorization:United States (Required)Additional Compensation:Annual targeted bonus X%Work Location:On site (San Diego, CA)EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
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