Principal Scientist (PhD), Biophysics

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.The Pfizer Oncology Research Unit in La Jolla is seeking an accomplished Principal Scientist to join the Biophysics & HTS group within Discovery Technologies. The successful candidate will evaluate drug interactions and protein behavior primarily using biophysical methods. In addition, the characterization of drug interactions may involve other biochemical or cellular methods. The successful candidate will work with a high degree of independence, providing biophysical insight on targets and ligands to impact project teams at a strategic level.ROLE RESPONSIBILITIESWork independently as a discipline expert to characterize small molecule-protein interactions using biophysical methods (SPR, HTRF, ITC, thermal stability-based assays, MST, native MS).Regularly represent the biophysics group on multi-disciplinary teams to provide scientific insights into the kinetics and thermodynamics of protein-ligand interactions.Display a growing knowledge and understanding of other disciplines relevant to early-stage drug discovery.Mentor and train colleagues in biophysical methods.Identify and integrate emerging biophysical technologies to strengthen current capabilities within the group.BASIC QUALIFICATIONSPhD degree in Biophysics, Biochemistry, Structural Biology or a closely related field with 3-5 years of drug discovery experience in a pharmaceutical industrial or academic laboratory setting.Demonstrated expertise in the use of biophysical methods (SPR, HTRF, ITC, MST, Native MS and thermal stability assays such as DSF) for characterization of protein-ligand interactions.Hands-on experience in high-throughput screening and plate-based pharmacology.Experience in handling a diverse range of recombinant proteins as tools in biochemical or biophysical assays.Knowledge and understanding in the areas of enzymology, mechanisms of drug action, and structural biology.Outstanding publication record reflecting scientific drive and creativity across multiple disciplines.Excellent oral and written communication skills, along with excellent interpersonal skills to facilitate knowledge sharing and scientific discussions. A team player.PREFERRED QUALIFICATIONSExperience in small-molecule screening using biophysical methods.Relevant experience in difficult-to-drug targets, targeted protein degradation, ADC would be valued.PHYSICAL/MENTAL REQUIREMENTSCandidate will be required to lift and transport large stacks and boxes of plates, plate stackers/hotels, and 5L bottles of liquids for use with the automated equipment regularly. Candidate may need to use step stools to climb and reach items above eye level. Candidate will also diagnose and repair equipment with various tools occasionally. Must be able to work safely in a laboratory environment with lab coat, protective eye wear and gloves. The job can require standing and walking for most of the day regularly.Relocation support available.WORK LOCATION ASSIGNMENTOn Premise.The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.Relocation assistance may be available based on business needs and/or eligibility.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

#J-18808-Ljbffr