Director DMPK

The company is dedicated to discovering and developing groundbreaking therapies to revolutionize cancer treatment. Our team, consisting of experienced leadership and a renowned scientific founder, focuses on translating innovative research into new therapeutic solutions. With a strong history in drug discovery and development, we have been instrumental in the creation of several clinical-stage compounds and an approved drug for the treatment of cancer and immune-mediated inflammatory diseases.Key Responsibilities:Lead DMPK efforts in support of drug discovery and early development for small molecules, working closely with the biology and chemistry teams.Report to the Executive Director of Preclinical R&D, collaborating with multifunctional teams across DMPK, biology, and chemistry to advance projects from discovery through early clinical development.Provide scientific expertise in DMPK assays and their application to solve broader project challenges, ensuring alignment with overall drug development goals.Represent DMPK on multiple cross-functional project teams, contributing to decision-making and project strategies.Mentor and train junior members of the DMPK team, fostering professional development and knowledge sharing.Manage in-vivo and in-vitro ADME/PK studies, ensuring timely and accurate data generation to support drug discovery efforts.Prepare and review the nonclinical sections of regulatory submissions, contributing to IND/CTA filings and other regulatory documentation.Oversee the contracting and management of CROs for nonclinical studies, ensuring high-quality deliverables.Demonstrate leadership in driving DMPK initiatives, maintaining strong organizational and reporting skills to meet project milestones.Qualifications:Significant experience in a leadership role within a multifunctional DMPK group at a pharmaceutical company.Proven ability to manage and oversee ADME/PK studies and provide technical leadership across multiple projects.Extensive knowledge of DMPK assays, with a strong understanding of their application to drug development challenges.Experience in writing and reviewing nonclinical regulatory submissions, with familiarity in managing CRO relationships for nonclinical studies.Highly motivated, with excellent organizational, communication, and mentoring skills.

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