Bristol-Myers Squibb
Associate Director Discovery Toxicology
Bristol-Myers Squibb, Princeton, New Jersey, us, 08543
Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Associate Director in Discovery Toxicology
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates. We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities), and engage with all other R&D functions to advance new assets in the BMS portfolio. Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high-quality drug candidates, and enable their clinical development.
A position is available for an Associate Director in Discovery Toxicology (DT) within the Pharmaceutical Candidate Optimization (PCO) organization at BMS. The incumbent will have responsibilities to identify and address toxicology issues across discovery programs that inform on program advancement, optimization of lead candidates and progression into development. Scientists in DT work with biology, chemistry and biotherapeutics representatives along with integrating across the other disciplines in PCO, namely drug metabolism and pharmacokinetics (DMPK) and pharmaceutics and bioanalytical sciences (DPAS) to ensure that quality drug candidates are advanced into development.
Responsibilities: Assess and develop plans for evaluating potential toxicity of new drug targets Apply appropriate models and testing strategies that inform on mechanisms of toxicity, address relevance to humans and design appropriate tools that can be used to proactively evaluate and predict liabilities of new drug entities Design, conduct, interpret toxicology studies within drug discovery and communicate these results across multiple disciplines and governance bodies Participate in drug discovery teams as a toxicology expert including communication of issues, experimental strategies for resolution and interpretation of results. Contribute to the collective research expertise in DT including laboratory efforts to advance new tools for advancing mechanistic toxicology research Discuss and enable transition of drug candidates into the BMS Development organization
Basic Qualifications: Bachelor's Degree 12+ years of academic / industry experience or Master's Degree 10+ years of academic / industry experience or PhD 8+ years of academic / industry experience with 4+ years of leadership experience
Preferred Qualifications: A Ph.D. in toxicology or other appropriate field and postdoctoral experience with 8 + years of experience in the pharmaceutical industry, with preference for experience in drug discovery and a minimum of 4+ years of leadership/people management experience. A broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity. Experience in computational toxicology, systems pharmacology or metabolism-mediated toxicity. The candidate should possess a strong and demonstrable skill set in design and implementation of mechanistic toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic or translational toxicology studies. The ability to design in vivo studies across species is also desired. Strong communication skills, both verbal and written, are essential. Additionally, the successful candidate is expected to be able to work in a highly collaborative manner with an enterprise mindset and patient-focused values.
Compensation: For California sites, the starting compensation for this job is a range from $178,000 - $22,000 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
Benefits: Eligibility for specific benefits listed on our careers site may vary based on the job and location. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care; Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP); Financial well-being resources and a 401(K); Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support; Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility; Parental, caregiver, bereavement, and military leave; Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources; Other perks like tuition reimbursement and a recognition program.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. #J-18808-Ljbffr
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Associate Director in Discovery Toxicology
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates. We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities), and engage with all other R&D functions to advance new assets in the BMS portfolio. Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high-quality drug candidates, and enable their clinical development.
A position is available for an Associate Director in Discovery Toxicology (DT) within the Pharmaceutical Candidate Optimization (PCO) organization at BMS. The incumbent will have responsibilities to identify and address toxicology issues across discovery programs that inform on program advancement, optimization of lead candidates and progression into development. Scientists in DT work with biology, chemistry and biotherapeutics representatives along with integrating across the other disciplines in PCO, namely drug metabolism and pharmacokinetics (DMPK) and pharmaceutics and bioanalytical sciences (DPAS) to ensure that quality drug candidates are advanced into development.
Responsibilities: Assess and develop plans for evaluating potential toxicity of new drug targets Apply appropriate models and testing strategies that inform on mechanisms of toxicity, address relevance to humans and design appropriate tools that can be used to proactively evaluate and predict liabilities of new drug entities Design, conduct, interpret toxicology studies within drug discovery and communicate these results across multiple disciplines and governance bodies Participate in drug discovery teams as a toxicology expert including communication of issues, experimental strategies for resolution and interpretation of results. Contribute to the collective research expertise in DT including laboratory efforts to advance new tools for advancing mechanistic toxicology research Discuss and enable transition of drug candidates into the BMS Development organization
Basic Qualifications: Bachelor's Degree 12+ years of academic / industry experience or Master's Degree 10+ years of academic / industry experience or PhD 8+ years of academic / industry experience with 4+ years of leadership experience
Preferred Qualifications: A Ph.D. in toxicology or other appropriate field and postdoctoral experience with 8 + years of experience in the pharmaceutical industry, with preference for experience in drug discovery and a minimum of 4+ years of leadership/people management experience. A broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity. Experience in computational toxicology, systems pharmacology or metabolism-mediated toxicity. The candidate should possess a strong and demonstrable skill set in design and implementation of mechanistic toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic or translational toxicology studies. The ability to design in vivo studies across species is also desired. Strong communication skills, both verbal and written, are essential. Additionally, the successful candidate is expected to be able to work in a highly collaborative manner with an enterprise mindset and patient-focused values.
Compensation: For California sites, the starting compensation for this job is a range from $178,000 - $22,000 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
Benefits: Eligibility for specific benefits listed on our careers site may vary based on the job and location. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care; Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP); Financial well-being resources and a 401(K); Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support; Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility; Parental, caregiver, bereavement, and military leave; Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources; Other perks like tuition reimbursement and a recognition program.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. #J-18808-Ljbffr