Associate Scientist - Oligonucleotide Chemistry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. At the Lilly Seaport Innovation Center in Boston, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support and is located in the heart of Massachusetts’ exploding science and technology cluster. We are seeking a highly motivated associate scientist to join our Genetic Medicine team. The successful candidate will have a strong research track record in chemistry and be analytically minded, systematic, and embrace data-driven decision making. The scientist will collaborate with multidisciplinary teams across key Lilly therapeutic areas (e.g. neuroscience, diabetes, immunology) to perform experiments to aid development of RNA oligonucleotide drug candidates for the next generation of RNA therapies. Key Responsibilities include:

Synthesize therapeutic oligonucleotides (ASO, siRNA, saRNA, and others) at different synthetic scales using automated solid-phase synthesizers. Routinely purify oligonucleotides using FPLC/HPLC and analyze purity by LC-MS. Independently problem-solve in the laboratory setting to overcome synthetic challenges and improve upon existing workflows. Maintain laboratory equipment and manage laboratory inventory/consumables. Visualize, summarize, and present results to team members. Partner with cross-functional teams to drive high-speed innovation. Embrace diversity of thought, background and experience to deliver innovative solutions. Possess strong communication and organizational skills regarding accurate record keeping, independent data analysis, and reporting of data in compliance with company standards. Basic Qualifications:

Bachelors and/or Masters in Chemistry or related field with experience in oligonucleotide synthesis. Additional Skills/Preferences:

Solid-phase synthesis experience with oligonucleotide synthesizers is strongly preferred. The ideal candidate will possess a solid understanding of RNA therapeutics. Excellent communication, interpersonal skills, and team-player mindset. Support the implementation of new technologies and workflows. Demonstrated technical proficiency and ability to create ideas for future work plans. High level of organization and attention to detail.

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