Brigham and Women’s Hospital
Microbiology Research Scientist
Brigham and Women’s Hospital, Boston, Massachusetts, us, 02298
Job Description - Microbiology Research Scientist (3312885)
Microbiology Research Scientist - (3312885)
The Massachusetts Host-Microbiome Center supports basic-science and human studies defining how our colonizing microbes affect health and disease. The research scientist microbiologist supports the research programs in the MHMC. Active Center projects investigate functions of microbes and microbial metabolism in host physiology, including modulating immune responses, metabolic syndromes, inflammatory bowel disease, and resistance to infectious agents. The Center also supports a multi-institutional program in genomic pathogen surveillance to counter multi-drug resistant organisms (MDRO) and inform area hospital infection control teams to halt spread of agents including MRSA, drug-resistant
Enterobacteriaceae , and
C. difficile . Example publications from Center projects are below: The candidate will manage workflows involving microbiologic testing and research-focused microbiologic analyses including quantitation of anaerobes from primary samples, and preparation of materials for microbial genomic, RNA sequencing, or 16S rRNA gene phylotyping or metagenomic analyses. The position will also take leadership on validating and optimizing new workflows and suggesting improvements for microbiology- and NGS-based analyses, and will also be involved in coordinating project plans with Center faculty and users of microbiologic platforms. Candidates will also have the opportunity to prepare materials for publication with co-authorship. Successful candidates must have good organizational, critical thinking, and communication skills, capacity to work effectively within a team environment, and on projects with defined timelines. Candidates must have at least 2 years of prior microbiology experience, that includes at least 1 year of experience with NGS workflows. The position offers the opportunity to work with internationally-renowned scientists on sequencing applications to inform infection prevention efforts in healthcare settings, and on the development of microbiota-informed therapies for human disease. Principal Duties and Responsibilities: Provide high-quality services to internal clients/investigators and external users. Ensure close coordination with clients for requested analyses and to optimize workflows to fit their needs. Perform molecular and microbiologic-based analyses, including methods using culture, DNA/RNA isolations, PCR, or next generation sequencing. Handle primary samples and isolates with appropriate sterile technique, and conditions for growth, including under anaerobic conditions in an anaerobic chamber. Oversee and work with other Center staff on pre-analytic processes to prepare materials, including for nucleic acid extractions and library prep. Follow appropriate SOPs for handling of samples and performing testing. Work with Center technical director and project management staff to monitor timelines for analyses and results. Monitor performance of supporting equipment including extractors, liquid handlers, and short and long read sequencers. Maintain high quality in technical work including following lab procedures, documenting, and assessing quality control parameters from analyses, maintaining accurate information in lab archive, compiling data and analyzing results into comprehensive and usable forms, LIMS, and project management software. Work with bioinformatics personnel to evaluate quality of sequencing runs and use of sequencing data for downstream analyses handled by computational teams. Coordinate data transfers with end users and other Center personnel. Oversee platform and testing improvements and optimization. Assist in preparation of materials for publications. Assist in the orientation and training of other employees in laboratory procedures. Qualifications and Skills: Masters or PhD in a biomedical or quantitative science; at least 3 years of prior experience working in microbiology and with next generation sequencing (NGS) approaches to analyze bacterial genomes and/or microbiome signatures. Excellent communication, organizational, and time management skills to prioritize tasks. Ability to work independently and as part of a team. Excellent computer skills with word processing, presentation, and spreadsheet programs. Excellent oral and written communication skills. Familiarity with project management software, including Smartsheets, a plus to monitor project timelines and aggregate sample runs; else training will be provided. BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
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Enterobacteriaceae , and
C. difficile . Example publications from Center projects are below: The candidate will manage workflows involving microbiologic testing and research-focused microbiologic analyses including quantitation of anaerobes from primary samples, and preparation of materials for microbial genomic, RNA sequencing, or 16S rRNA gene phylotyping or metagenomic analyses. The position will also take leadership on validating and optimizing new workflows and suggesting improvements for microbiology- and NGS-based analyses, and will also be involved in coordinating project plans with Center faculty and users of microbiologic platforms. Candidates will also have the opportunity to prepare materials for publication with co-authorship. Successful candidates must have good organizational, critical thinking, and communication skills, capacity to work effectively within a team environment, and on projects with defined timelines. Candidates must have at least 2 years of prior microbiology experience, that includes at least 1 year of experience with NGS workflows. The position offers the opportunity to work with internationally-renowned scientists on sequencing applications to inform infection prevention efforts in healthcare settings, and on the development of microbiota-informed therapies for human disease. Principal Duties and Responsibilities: Provide high-quality services to internal clients/investigators and external users. Ensure close coordination with clients for requested analyses and to optimize workflows to fit their needs. Perform molecular and microbiologic-based analyses, including methods using culture, DNA/RNA isolations, PCR, or next generation sequencing. Handle primary samples and isolates with appropriate sterile technique, and conditions for growth, including under anaerobic conditions in an anaerobic chamber. Oversee and work with other Center staff on pre-analytic processes to prepare materials, including for nucleic acid extractions and library prep. Follow appropriate SOPs for handling of samples and performing testing. Work with Center technical director and project management staff to monitor timelines for analyses and results. Monitor performance of supporting equipment including extractors, liquid handlers, and short and long read sequencers. Maintain high quality in technical work including following lab procedures, documenting, and assessing quality control parameters from analyses, maintaining accurate information in lab archive, compiling data and analyzing results into comprehensive and usable forms, LIMS, and project management software. Work with bioinformatics personnel to evaluate quality of sequencing runs and use of sequencing data for downstream analyses handled by computational teams. Coordinate data transfers with end users and other Center personnel. Oversee platform and testing improvements and optimization. Assist in preparation of materials for publications. Assist in the orientation and training of other employees in laboratory procedures. Qualifications and Skills: Masters or PhD in a biomedical or quantitative science; at least 3 years of prior experience working in microbiology and with next generation sequencing (NGS) approaches to analyze bacterial genomes and/or microbiome signatures. Excellent communication, organizational, and time management skills to prioritize tasks. Ability to work independently and as part of a team. Excellent computer skills with word processing, presentation, and spreadsheet programs. Excellent oral and written communication skills. Familiarity with project management software, including Smartsheets, a plus to monitor project timelines and aggregate sample runs; else training will be provided. BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
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