Research Bioinformatician I - Knott Lab - Center for Bioinformatics and Function

When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it’s just one of the many reasons we rank as one of the top hospitals in the nation by U.S. News & World Report. From working with a team of committed healthcare professionals to using state-of-the-art facilities, you’ll have everything necessary do something incredible—for yourself and for others!

Are you ready to be a part of breakthrough research?

The Knott laboratory is searching for computational scientists to develop and apply machine learning tools to study next-generation single-cell datasets. The Knott lab is located in the Center for Bioinformatics and Functional Genomics at Cedars-Sinai Medical Center, in Los Angeles, California. The lab focuses on understanding the molecular mechanisms of disease using a combination of genomics, computational biology, and functional studies in animal models. To learn more, please visit Knott Research Lab | Cedars-Sinai.

The Research Bioinformatician I performs general bioinformatics analysis and software support for projects involving in omics. The RBI manages omic data including loading and querying data from database system(s) and public repositories, and transforms and merges multilevel omic data into user-friendly formats.

The RBI assists in the development, testing, and maintenance of modular software pipelines, and provides daily bioinformatics data analysis, preliminary interpretation of the data, and reports of the results for possible publications.

Primary Job Duties & Responsibilities:

• Provides general bioinformatics analysis support for omic projects and mainly responsible for data analysis and software compilations including next generation sequence alignment, polymorphism identification, expression analysis, and visualization tools and browsers.
• Summarizes data analyses results in the form suitable as the basis for the first draft of written reports, and makes preliminary interpretations of the data.
• Assists in development, testing, and maintenance of modular software pipelines for genome sequencing, assembly, annotation, metagenomic analysis, and genotyping using high-throughput sequencing platforms including 454, Illumina, and Pacific Biosciences.
• Manages data including loading and querying data from database systems, downloading omic data from public repositories, and transforming data to the necessary formats.
• Helps to identify, evaluate, and incorporate relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology.

Education:

• Bachelor’s Degree in Computer Science, Electric Engineering, Computational Biology, or Bioinformatics, or relevant fields (e.g. Biology with strong quantitative training, biostatistics with a concentration in bioinformatics). Master's degree is preferred.

Experience and Skills:

• No experience is required.
• Background and work knowledge in algorithms, scientific computing, and machine learning or statistics, Familiar with C/C++, Java, Perl, python, and the Unix (Linux) environment, Experiences in manipulating, analyzing, and annotating very large genomic (e.g. NGS) data sets, both in exploratory and pipelined fashions, will be a plus.
• Experiences in manipulating, analyzing, and annotating very large genomic (e.g. NGS) data sets, both in exploratory and pipelined fashions, will be a plus.