Senior Scientist I, Chemical Biology, Target Qualification

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:Revolution Medicines’ Cancer Biology group is looking for a talented, creative, and motivated scientist with a strong background in chemical biology, biochemistry, and cell biology to support early target discovery, screening, and validation efforts for novel oncology programs. The successful applicant will join the Chemical Biology and Proteomics team within Discovery Biology. They will work in a cross-functional team with chemists, cell, and structural biologists and utilize a wide array of molecular biology, biochemical and cellular assays to identify and validate novel targets for RevMed’s unique molecular glue platform. They will help inform and support high-throughput screening efforts and work closely with the mass spectrometry team to support MS-based proteomics workflows. The ideal candidate will have hands-on experience with a number of biochemical and cellular assays, expertise in assay development and troubleshooting, as well as a strong background in cancer biology and novel oncology targets. Above all, we are looking for a highly motivated and driven team player to join our diverse and talented team of scientists at RevMed.Responsibilities:Design, execute, and troubleshoot biochemical and cellular assays for novel oncology targetsStay on top of relevant literature to identify novel target opportunitiesWork with HTS team to conduct, analyze and follow up on biochemical and cellular screensPerform mechanistic studies as part of hit validation effortsCollaborate cross-functionally with biology, biochemistry, chemistry and structural biology colleagues at RevMedManage projects at external CROsGenerate data in a timely manner and maintain detailed experimental recordsRegularly and effectively communicate findings at project team and company meetingsRequired Skills, Experience and Education: PhD in chemical biology, biochemistry, or related discipline plus 5 years of relevant industry experienceHands-on experience culturing, manipulating and characterizing mammalian cells: cell culture, viral transduction, CRISPR/Cas9 gene editing, viability and mechanistic assaysExperience with standard molecular biology and biochemistry assays, including characterizations of covalent target engagementExperience interrogating PPIs, including proximity labelingAbility to drive projects and work independentlyStrong problem-solving skills with sound technically driven decision-making abilityEffective written and verbal communication skills as well as interpersonal skillsA creative team-player with capacity to be effective in a dynamic company environmentPreferred Skills, Experience and Education:Hands-on experience with cellular and phenotypic screens (genetic or pharmacological), hit finding and validationKnowledge of molecular glues and similar modalitiesSolid background in cancer biology and cancer-relevant pathways (both tumor-cell intrinsic and extrinsic), novel oncology targetsExperience with large-scale data interpretation and visualizationThe base salary range for this full-time position is $135,000 to $175,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.#LI-Hybrid   #LI-LN1