Senior Scientist, Translational Medicine – Auto-immune Diseases

For Current Kite Pharma Employees and Contractors:Please log onto your Internal Career Site to apply for this job.We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.Job DescriptionThe Senior Scientist will design and execute biomarker and translational strategy for the clinical development of Kite’s chimeric antigen receptor (CAR-T) programs in auto-immune indications. As a member of the Translational Medicine team, you will be at the intersection of Research and Clinical Development, providing valuable insight into the function of CAR-T cells in patients, the investigation of mechanisms of response and toxicity and the development of potential prognostic and predictive tools. You will facilitate clinical trial execution, synthesize scientific data, communicate key findings cross-functionally and regulatory filing.Job ResponsibilitiesDirects and establishes pharmacokinetic and pharmacodynamic (PK/PD) analysis to support clinical pharmacology for CAR T clinical trials in Auto-immune indicationsServes as Biomarker lead on clinical study teams to oversee delivery of pharmacology data and documentation required for early phase, as well as pivotal and registrational study filingsReviews and contributes to clinical protocol design and study activitiesIdentify and establish agreements with contract research organizations (CRO) and support the transfer of novel methodsCollaborates with Clinical development teams including Clinical Operations, Regulatory, Clinical Data Management and Biometrics/Stats to advance data acquisition and analyses of clinical trial dataGuides the resolution of clinical pharmacology/translational queries from regulatory agencies, supports writing and reviewing responses to regulatory queries.Support the preparation of data packages for publication, presentation and/or submission to regulatory agenciesCollaborates with Bioinformatics, Statistical and analytical teams for exploratory biomarker correlative studies around disease biology and CAR T functionalityContribute to external scientific discussions/research collaborations and publications and engagement with key opinion leaders in the fieldBasic QualificationsDoctorate and 2+ years of scientific experienceORMaster’s and 6+ years of scientific experienceORBachelor’s and 8+ years of scientific experiencePreferred Qualifications Familiarity and experience with clinical and biomarker operationsPrior experience in Regulatory filingsStrong background in auto-immune diseases, immunology and/or cancer immunotherapyIn-depth understanding of clinical landscape, evolving therapy, competitive scenariosThorough understanding of clinical, translational, and mechanistic dataUnderstanding of early or late-stage drug and translational development process; including clinical trial experience in industry or academiaFamiliarity with bioanalytical assay development and validation in a GxP environmentExperience working with engineered T cells, immunophenotyping, and NGS-based approaches to profile the function of immune cellsComfortable in a matrixed and fast-paced company environment and able to adapt to changing prioritiesStrong collaboration, excellent interpersonal and communication skillsProficient with data presentations to communicate to a diverse cross-functional audienceMaintain a high degree of accuracy and attention to detailsPh.D. degree in biology-related field (immunology, bioinformatics or a closely related field)The work you do at Kite will help change how cancer is treated and ensure patients and their families have more time together. Ready to create more tomorrows with us? Hit apply.#LI-ML1#IND123The salary range for this position is: $165,580.00 - $214,280.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.For additional benefits information, visit: * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit . Sign up to follow @KitePharma on Twitter at .For jobs in the United States:As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACTYOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACTPAY TRANSPARENCY NONDISCRIMINATION PROVISIONOur environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.For Current Kite Pharma Employees and Contractors:Please log onto your Internal Career Site to apply for this job.SummaryLocation: United States - California - Foster City; United States - California - Santa MonicaType: Full time