Principal Scientist

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.The PositionWe advance science so that we all have more time with the people we love.Roche Diagnostics acquired Stratos Genomics () in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX). You will engineer and synthesize the molecular building blocks for our novel technology.  These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing.   The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes.  We are looking for people who are excited about the significance of our technology and want to make SBX successful. The Opportunity:Research, design and execute innovative and well-controlled experiments, with high attention to detail.Lead, mentor and drive cross functional teamsIdentify and troubleshoot problems in creative ways.Contribute to the definition and timely achievement of project goals.Develop SOPs to aid in the production of reagents and starting materialsParticipate in the production of reagents and starting materials.Perform data analysis and protocol development.Maintain accurate, detailed and reliable laboratory records.Present findings at group or departmental meetings.Maintain the lab’s cleanliness and organization.Develop and propose improved processes to fulfill the above functions.Who You Are:You have 6 years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry and/or complex/multi-step organic synthesis.You have a Bachelor’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field  and 10  years of experience  You have a Master’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 9 years of experience  You have a  PhD Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 6 years of experience  Ideally, you will have:Demonstrated ability to understand and develop chemistry for:NucleotidesPhosphoramiditesHeterocyclesAmino AcidsBio-conjugationsMature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage.Technical background in next-generation DNA sequencingExperience with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting.​***Please include a cover letter outlining why you want to work with us, your specific interest in SBX technology and how you would contribute, this is important.***The expected salary range for this position based on the primary location of Seattle, WA is $117,700-218,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed here: BenefitsRelocation benefits are available for this position.   Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.SummaryLocation: SeattleType: Full time