Scientist, AAV Production (Regeneron Genetic Medicines)

We are seeking a skilled and motivated Scientist for our AAV production team within Regeneron Genetic Medicines (RGM). You will join a team of junior and experienced scientists and be responsible for the production, purification, and characterization of research-grade AAV. In this role, you will be expected to work methodically and with minimal supervision to perform various in vitro assays and protocols. We hope you are excited to support development of Regenerons gene therapy portfolio and technology development through the delivery of high-quality viral vectors. As a Scientist, a typical day might include: Performing large-scale production of AAV vectors using transient transfection of adherent and suspension HEK 293 Purifying AAV vectors using ultracentrifugation and chromatography Conducting an array of assays to characterize the purity, quantity, and potency of AAV Optimizing various steps of AAV production and purification protocols to iteratively improve yield and quality Regularly troubleshooting technical issues related to AAV production and purification Collaborating with colleagues in both technology centers and therapeutic areas Ensuring proper maintenance of equipment and organization of lab environment Providing technical support and training to colleagues This might be the right role for you if: You are passionate about genetic medicines and supporting gene therapy development You enjoy problem solving and adapting to new technologies and challenges You are comfortable being in a support role and performing routine tasks You are capable of working independently and as part of a team In order to be considered for this role, you must have at least a BS/MS with a minimum of 6 years of relevant experience. We need someone with extensive experience doing production and purification of AAV. Must have experience with immunoassays, qPCR, SDS-PAGE, Western Blot, and tissue culture. Experience with suspension cell culture and bioreactors is strongly preferred. Familiarity with ddPCR/dPCR, mass photometry, and other analytical techniques is very advantageous. Experience developing and optimizing protocols, assays, or SOPs is highly desirable. Does this sound like you? Apply now to take your first step towards living the Regeneron Way We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $92,500.00 - $151,100.00