Senior or Principal Scientist, Protein Engineering, Biologics Drug Discovery Ste

We are seeking a highly motivated and ambitious Protein Engineer to join our stealth-stage

biotech startup. The successful candidate will develop novel biologics for geriatric disorders.

This is a unique opportunity to shape the direction of our protein engineering efforts. We are

looking for someone who has broad familiarity with modern antibody discovery and protein

engineering techniques, strong problem-solving skills, and a willingness to learn quickly.

Location: San Francisco, CA

Key Responsibilities:

● Lead antibody discovery campaigns conducted externally with CROs partners and

evolve leads internally using phage or yeast display libraries

● Use protein engineering techniques to develop protein fusions with optimized

expression, pharmacokinetics, and developability properties

● Develop and optimize moderate- and high-throughput assays to screen and characterize

engineered protein variants

● Analyze large datasets from next-generation sequencing of protein and antibody libraries

● Characterize lead candidates using biochemical, cell-based, and in vivo assays

● Collaborate closely with the founders to drive the project forward

Qualifications:

● PhD in Protein Engineering, Biochemistry, or related field with at least 5 years of

post-graduate experience. Hiring level will be commensurate with experience and skillset

● Experience assembling and screening yeast or phage display libraries, preferably

incorporating NGS-based workflows

● Background in biochemistry, molecular biology, and protein expression & purification

● Familiarity with analytical methods for characterizing the biophysical properties of

proteins (e.g., SE-HPLC, DLS, DSF , SPR, BLI, etc)

● Characterize protein function with ELISAs, flow cytometry, and activity reporter assays

● Proficiency in data analysis and programming (e.g. Python, R)

● Strong communication and collaboration abilities

● Excellent problem-solving skills and ability to work independently

● Entrepreneurial mindset and enthusiasm for working in a fast-paced startup environment

The ideal candidate will be drawn to hard problems: proactive, creative, and excited for new

challenges. You should be comfortable wearing multiple hats and adapting as our needs evolve.

This role offers significant opportunities for growth and leadership as we expand our team.

If you are passionate about protein engineering and developing new drugs to treat geriatric

diseases, we want to hear from you!

#J-18808-Ljbffr