Postdoctoral fellow / Research Scientist

Postdoctoral fellow positions and research scientist positions are available in Dr. Min Dong’s lab at Boston Children’s Hospital / Harvard Medical School. Our laboratory has a broad interest in microbial toxins, bacterial pathogenesis, and engineering therapeutic proteins. Along these lines of basic research, we are keen on developing microbial protein-inspired novel therapeutics for treating genetic diseases, cancer, pain, and other neurological disorders. We have a multi-disciplinary team crossing microbiology, bioinformatics, structural biology, protein engineering, cell biology, insect biology, and neuroscience fields. Recent achievements include identification of receptors for

C. difficile

toxins and insecticidal toxins via genome-wide CRISPR-Cas9 screen (Nature, 2023, 622:611; Nature, 2016, 538:350, Science, 2018, 360:664; Cell Host and Microbe, 2020, 27:782; Nature, 2022, 610: 349-355), identification and characterization of novel toxins (Nature Communications, 2017, 8:14130; Cell Host and Microbe, 2018, 23:169, Cell, 2022, 185:1), and protein engineering of botulinum neurotoxins (Nature Communications, 2017, 8:53; Science Translational Medicine, 2021, 13:eaaz4197; Science, 2021, 371:803). Please see lab website for details:

http://donglab.hms.harvard.edu . Strong background in the following areas are an advantage but not required: Microbial genetics (e.g. in

streptomyces, enterococcus,

or

C. difficile ),

Drosophila genetics , insect biology, pain and sensory neuron biology, protein design, engineering, and structure biology, mouse models, and immunology. Interested candidates please forward your curriculum vitae and names of three references to Dr. Min Dong by email:

donglab@childrens.harvard.edu .

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