Bristol Myers Squibb
Research Investigator/Sr. Research Investigator/Associate Director, Clinical Pha
Bristol Myers Squibb, Princeton, New Jersey, us, 08543
Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
The Clinical Pharmacology and Pharmacometrics (CP&P) team at BMS is responsible for the pharmacology and pharmacometric support for all pipeline assets throughout the clinical development lifecycle. Composed of pharmacologists, pharmacometricians, data scientists and modelers, this group oversees the pharmacokinetic evaluation, pharmacometric exposure-response evaluation, quantitative systems pharmacology modeling, physiologically based pharmacokinetic modeling and model based meta-analysis of assets covering all therapeutic modalities, including small molecules, traditional and complex biologics and next gen cell therapies. All therapeutic areas are supported.
The CP&P team interacts with discovery and translational scientists, project leadership, early and late clinical development teams and commercial colleagues to provide input on clinical pharmacology profiling, dose optimization, formulation bridging, and combination strategies to enable faster and more effective drug development informed by core scientific principles and data.
Responsibilities
Independently contribute
to compound development across various development phases. Represent
Clin Pharm on asset teams and at governance meetings based on proficiency. Provide input
to Phase 2/3 clinical study design and registrational strategy. Accountable for the
Clinical Pharmacology Plan. Lead
design of clinical pharmacology studies and manage data analysis, interpretation, and reporting. High proficiency
in PK, PK/PD, and model informed drug development (MIDD) principles and analyses. Collaborate
on cross-functional drug development teams, and regulatory submissions; serve as Clinical Pharmacology subject matter expert. Lead and participate
in departmental initiatives and represent CP&P on cross-functional initiatives/workstreams/taskforces. Participate
in interactions with health authorities; serve as Clinical Pharmacology subject matter expert. Provide
critical expertise to Business Development teams to assess external acquisitions. Requirements
Advanced Degree in related field (MS, Ph.D. or PharmD). For Associate Director level with Ph.D. approximately 5+ years experience with demonstrated progression in clinical pharmacology and Pharmacometrics experience. For Sr. Research Investigator, with Ph.D. approximately 2+ years experience with demonstrated progression in clinical pharmacology and Pharmacometrics. For Research Investigator, with Ph.D. approximately 0-2 years experience with demonstrated progression in clinical pharmacology and Pharmacometrics. Demonstrated ability to work in a dynamic team-oriented environment. Expertise in general drug development. Expertise in small molecule and/or biologic drug property characterization. Demonstrated stakeholder management with strong influence/leadership. Quantitative data analysis, POP PK/PD, and data visualization skills. Programming experience (e.g., NONMEM, Phoenix NLME, Monolix, R, WinNonlin, SAS, Splus etc.).
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Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
The Clinical Pharmacology and Pharmacometrics (CP&P) team at BMS is responsible for the pharmacology and pharmacometric support for all pipeline assets throughout the clinical development lifecycle. Composed of pharmacologists, pharmacometricians, data scientists and modelers, this group oversees the pharmacokinetic evaluation, pharmacometric exposure-response evaluation, quantitative systems pharmacology modeling, physiologically based pharmacokinetic modeling and model based meta-analysis of assets covering all therapeutic modalities, including small molecules, traditional and complex biologics and next gen cell therapies. All therapeutic areas are supported.
The CP&P team interacts with discovery and translational scientists, project leadership, early and late clinical development teams and commercial colleagues to provide input on clinical pharmacology profiling, dose optimization, formulation bridging, and combination strategies to enable faster and more effective drug development informed by core scientific principles and data.
Responsibilities
Independently contribute
to compound development across various development phases. Represent
Clin Pharm on asset teams and at governance meetings based on proficiency. Provide input
to Phase 2/3 clinical study design and registrational strategy. Accountable for the
Clinical Pharmacology Plan. Lead
design of clinical pharmacology studies and manage data analysis, interpretation, and reporting. High proficiency
in PK, PK/PD, and model informed drug development (MIDD) principles and analyses. Collaborate
on cross-functional drug development teams, and regulatory submissions; serve as Clinical Pharmacology subject matter expert. Lead and participate
in departmental initiatives and represent CP&P on cross-functional initiatives/workstreams/taskforces. Participate
in interactions with health authorities; serve as Clinical Pharmacology subject matter expert. Provide
critical expertise to Business Development teams to assess external acquisitions. Requirements
Advanced Degree in related field (MS, Ph.D. or PharmD). For Associate Director level with Ph.D. approximately 5+ years experience with demonstrated progression in clinical pharmacology and Pharmacometrics experience. For Sr. Research Investigator, with Ph.D. approximately 2+ years experience with demonstrated progression in clinical pharmacology and Pharmacometrics. For Research Investigator, with Ph.D. approximately 0-2 years experience with demonstrated progression in clinical pharmacology and Pharmacometrics. Demonstrated ability to work in a dynamic team-oriented environment. Expertise in general drug development. Expertise in small molecule and/or biologic drug property characterization. Demonstrated stakeholder management with strong influence/leadership. Quantitative data analysis, POP PK/PD, and data visualization skills. Programming experience (e.g., NONMEM, Phoenix NLME, Monolix, R, WinNonlin, SAS, Splus etc.).
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