Principal Associate Scientist, LNP Discovery

Company Overview:

Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients.

Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were seeking to apply the concept of the emerging field of mRNA therapeutics. Strand's technology is therapeutic-area and mRNA modality agnostic where therapeutic proteins are encoded onto modified, self-replicating, or circular mRNA backbones which in turn are programmed with cell-specific sensors and circuits.

Today, Strand has established three platforms with one clinical stage asset and several programs in preclinical development as well as early discovery. Our lead program, STX-001, is currently being evaluated in a phase 1 clinical trial for solid tumors. Our corporate headquarters is located in the Fenway district of Boston, Massachusetts with an additional site based in Watertown, Massachusetts.

Become the next standout single strand!

Job Summary:

Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.

We are looking for a highly motivated and innovative candidate for the role of Principal Associate Scientist, LNP Discovery. The expectation is that the candidate will have experience in the formulation and characterization of LNPs. The candidate will be expected to work in an innovative, fast-paced, cross-collaborative biotech environment and contribute in multi-disciplinary team activities to advance our platform. This role will have the opportunity to collaborate with functions outside of LNP Discovery such as Translational biology, LNP Process Development, and Analytical Development.

Primary Responsibilities:

• Help advance Strand's mRNA delivery platform and capabilities.
• Contribute to LNP innovation, engineering and process screening to support pipeline programs.
• Characterize the physiochemical properties of LNPs and components using standard or newly developed in-house assays.
• Evaluate the delivery capability of LNPs using standard or newly developed cell-based assays.
• Execute LNP composition optimization and screening assays.
• Compile data reports and communicate the results with relevant team(s).
• Produce LNP formulations to support internal and partnered programs.
• Research and identify new opportunities and novel project ideas related to mRNA delivery that support Strand's vision.
• Write study protocols, technical reports and SOPs that support the drug discovery efforts of Strand.

Qualifications:

• B.S. or Advanced Degree in Pharmaceutical Sciences, Biomedical Engineering, Chemical Engineering or other relevant scientific discipline.
• 5-6+ years of experience with a focus on discovery & development of LNP formulations with nucleic acid-based payloads required.
• Experience with production and analytical characterization of mRNA LNPs (DLS measurement, RiboGreen assay, luciferase assay etc.).
• Experience with mammalian cell culture and cell-based assays is highly preferred.
• Familiarity with high throughput screening of mRNA LNPs would be a plus.
• Excellent knowledge of the scientific literature in the field of mRNA delivery.
• Highly analytical, decisive, and goal-oriented while maintaining the highest scientific and ethical standards.
• Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
• A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.

Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand's goals.

Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.

Job Type: Full-time

Salary: commensurate with role and experience