Senior Scientist

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies that matter most. The Oncology Research Unit in La Jolla, CA is focused on supporting the execution and diversification of the Oncology Research pipeline and translating discoveries into novel therapeutics. Our team takes a holistic approach to understand the interplay of tumor, stromal, and immune cells in the tumor microenvironment, striving to define the axes of intercellular communication that could be leveraged to generate novel therapeutics. Our T cell biology team is looking for a motivated and creative Senior Scientist to uncover the next generation T cell engagers to change patients' lives. What You Will Achieve Identify and evaluate novel T cell-targeted approaches in the field of Cancer Immunotherapy. Advance our pre-clinical drug discovery programs in a fast-paced and highly collaborative team of motivated and scientifically rigorous scientists. Contribute to study execution, data analysis and coordinate activities across research team to drive program progression. Be recognized as a scientific contributor at the team and project level. Utilize your knowledge of T cell biology and cancer immunotherapy to impact projects and strategy to deliver novel T cell engagers. Develop novel projects and new ideas frequently. How You Will Achieve It Contribute to discovery research programs up to early clinical development by providing scientific and technical T cell biology expertise. Work in a matrixed environment and collaborate with multiple disciplines to identify and pursue the most promising drug candidates. Support a team of scientists to conceptualize, design, and execute experiments and support target identification/validation, mechanism of action studies, and biomarker identification. Interpret, present, and document experiments as well as preparation of reports. Assist in designing, planning, and executing project strategies to ensure efficient and effective decision-making. Communicate strategy and results accurately and concisely to stakeholders in a multidisciplinary team environment. Publish results in scientific peer-reviewed journals and presentations at internal, national, and international meetings. Qualifications PhD degree in Immunology or a related discipline. Minimum of 2 years relevant industry immune-oncology drug discovery and development experience. Technical and scientific experience developing multi-specific antibodies targeting T cells. Broad technical and scientific expertise assessing T cell phenotypes and function (flow cytometry, incucyte, MSD, confocal microscopy) in preclinical animal and ex vivo models. Experience contributing to a research program, ideally as biology/research project lead and experience assisting in designing, planning, and executing biology project strategies. Experience in collaborative research in Oncology drug discovery programs in a fast-paced environment. Strong written and verbal communication skills. PHYSICAL/MENTAL REQUIREMENTS Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Must be willing to work after hours as needed to ensure study integrity. Relocation assistance may be available based on business needs and/or eligibility. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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