Principal Scientist II - Neuroscience

Job Description Summary Onsite: Cambridge, MA The Neuroscience Disease Area within Biomedical Research at Novartis is a global research organization striving to develop impactful medicines for people living with severe neurological and neurogenetic diseases. We are a team of world-class drug hunters and experts in mechanisms of Neurodegeneration, Neurodevelopment, Inflammation, and Neuromuscular disorders, driving a portfolio that includes multiple indications and therapeutic approaches. We seek a highly motivated teammate, working at the intersection of lipid metabolism/transport, synaptic & circuit biology, and neurodegeneration, to join us in creating and delivering the next generation of transformative therapies to patients worldwide. If this sounds like you, apply now! Job Description Your Key Responsibilities: Support Neuroscience discovery programs based on high-quality experimental data that incorporates approaches addressing the relationship between lipid signaling, synaptic function, and neuronal-glia crosstalk in Neurodegeneration. Formulate and/or lead novel projects with multidisciplinary teams, and/or enable matrix collaboration on projects/technologies to achieve creative results for impact on Neuroscience goals. Be adept at executing experiments in the lab and intellectually driving projects forward. Develop and implement assays to assess synaptic structure, function, and/or plasticity in disease models. Evaluate the impact of therapeutic candidates in neural/synaptic/circuit function. Play a role in identifying tractable therapeutic targets and initiating exploratory efforts to modulate them. Provide expert input into understanding the genetics and biology of neurodegenerative disorders. Establish priorities and target dates to enable data-driven advancements in portfolio and/or platform projects. Manage, mentor, train and empower associates to ensure technical growth, development, compliant data documentation, and high-impact deliverables. What You'll Bring to the Role: MS in Neuroscience or closely related field with 10+ years of relevant pharmaceutical/biotech experience. Hands-on expertise in complex in vitro / ex vivo / in vivo model systems and circuit level analysis that leverages electrophysiological, cell biological, molecular, and/or anatomical approaches. Deep biological knowledge of neurodegeneration and/or neurogenetic disorders, including mechanisms of disease progression and core drivers of disease. Ability to communicate effectively and present complex and/or new ideas with clarity and simplicity. A team-first and portfolio mindset are qualities that we strongly seek and value. Preferred Qualifications: PhD in Neuroscience or related field and 5+ years of pharm/biotech experience. Aptitude to work in a matrix structure and demonstrable experience collaborating/managing multidisciplinary teams directly and/or by influence. Salary Range $124,000.00 - $186,000.00

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