Senior Director, Medical Affairs

Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’s mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. We have raised nearly $500M since inception in February 2024 from top-tier investors and our first program is expected to be in the clinic in the first quarter of 2025. For more information, visit www.orukatx.com As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger. Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture. Job Title: Senior Director, Medical Affairs Location: HYBRID

(Waltham, MA or Menlo Park, CA)

OR REMOTE Role Overview: Oruka is looking for Senior Director, Medical Affairs to lead the development of medical strategy, planning, and execution of medical affairs activities within dermatology and rheumatology therapeutic areas. The ideal candidate will have an advanced scientific degree and extensive experience within medical affairs leadership and field-based teams. This individual will play a key role in both external scientific engagement and internal leadership, overseeing a team of Medical Science Liaisons (MSLs) while contributing to the success of clinical trials of Oruka’s rich pipeline. Summary: Leads medical strategy and medical affairs activities aiming to engage scientific community with high quality communication and support clinical trials with proficient MSL team. Key Responsibilities: Develops and leads medical affairs strategy and tactics, including scientific exchange and publications, annual medical planning, field communications, and advisory boards. Develops and cultivates long-term strategic partnerships with clinical investigators, key opinion leaders, societies, collaborative groups, advocacy groups, and other healthcare collaborators. Keeps abreast of scientific information and technology through conferences and medical literature and acts as a specific therapeutic area resource. Gathers feedback, data, or information during routine activities that can help the company better comprehend medical or scientific needs, priorities, or concerns of scientific community and patients. Supports the design and conduct of clinical trials. Leads, mentors, and manages a team of Medical Science Liaisons (MSLs), providing strategic and professional development direction. Qualifications: Advanced degree in life sciences (PharmD, PhD, MD/DO, or equivalent) is required. Minimum of 5 years’ experience as Medical Director leading strategic plans and initiatives in Medical affairs. Field-based medical and team management experience preferred. Ability to organize, prioritize, and work effectively in a constantly changing environment. Strong ability to critically analyze, summarize and communicate scientific data. Good understanding of drug development, including clinical trial methodology, data analysis and interpretation, regulatory requirements governing clinical trials. Strong interpersonal skills in developing and maintaining positive and successful stakeholder relationships. Experience in Dermatology, Rheumatology, and other immune conditions preferred. Compensation: An appropriate financial package will be developed for the successful candidate to include a competitive base salary and equity, with a performance-related bonus opportunity. The anticipated salary range for candidates is $240,000-270,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc. Oruka is a multi-state employer and this salary range may not reflect positions that work in other states. Job Location: Position is hybrid, based in

Waltham, MA or Menlo Park, CA

with 3 days/week in-office requirement.

Remote candidates will be considered. We're looking forward to hearing how you can contribute to our team and mission. Join us in shaping the future of our company and making a real impact every day. What We Offer: A chance to be part of a vibrant small-company culture where your work can directly impact bringing new medicines to patients. Competitive salary and benefits package. Opportunities for professional growth and development. Apply for this job

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