Principal Research Scientist I

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company with a mission to develop innovative therapies to address the world's most complex and serious diseases. AbbVie employs approximately 47,000 people worldwide and markets medicines in more than 175 countries.

The AbbVie portfolio consists of several marketed products in areas including eye care, immunology, oncology, virology, and women’s health as well as a pipeline containing multiple promising new molecules being studied in hundreds of clinical trials or advancing from Discovery into Development. AbbVie is a global organization with US research sites in Boston (Cambridge and Worcester, MA), Chicago (North Chicago, IL), and the San Francisco Bay Area (South San Francisco, CA). The small molecule portfolio (degraders, protein-protein interaction inhibitors, covalent inhibitors, peptides etc.) is comprised to deliver first in class drugs utilizing novel mechanisms of action against targets in various therapeutic space.

The Quantitative, Translational and ADME Sciences (QTAS) group is searching for an experienced project representative to provide small molecule project support across all therapeutic areas for molecules in discovery and clinical development. The position requires close collaboration with Discovery and Development project teams, clinical pharmacology, and other stakeholders, developing and executing QTAS and PK/PD strategies necessary to facilitate the advancement of our pipeline.

Key Responsibilities:

• Serve as a QTAS representative on multidisciplinary project teams supporting the development of novel small molecules; collaborate with project team members (e.g., discovery, toxicology, clinical pharmacology) and groups within QTAS to generate relevant data guiding target validation, biomarker selection, and candidate selection.
• Develop and drive the QTAS and PK/PD strategy for small molecule discovery, preclinical, and clinical development of projects to support decisions and milestone transitions.
• Effectively communicate QTAS and PK/PD strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions.
• Demonstrate thorough understanding of ADME sciences and PK/PD aspects necessary to optimize drug candidates.
• Coordinate and request ADME, PK and PK/PD studies in a timely manner and communicate protocols, timelines, needs and results back to team, ensuring optimized cycle times.
• Integrate ADME, PK, PK/PD data with discovery biology data and provide thought leadership to project teams as a functional representative.
• Prepare QTAS sections of regulatory submission documents (IND, IB, NDA); provide responses to regulatory questions and ensure generation of appropriate reports.
• Mentor junior project reps.

• PhD in Biochemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or related area with 6+ years of experience in the pharmaceutical or biotechnology industry, or MS with 12+ years, or BS with 14+ years of industry experience.
• Experience independently representing QTAS on small molecule project teams is required (expertise with novel modalities is preferred).
• Expertise in PK analysis and relevant data analysis software such as Phoenix/WinNonlin is required.
• Ability to quickly adapt in-house visualization tools for data interpretation and presentation.
• Strong understanding of Drug Metabolism, PK, PK/PD modeling, human PK and DDI prediction strategies.
• Demonstrated scientific leadership including generating original scientific investigative strategies and guiding those efforts to an effective and productive outcome.
• Recognized expert in his/her discipline.
• Demonstrated publication or patent record; lead/senior author contributions a plus.
• Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment.
• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver.
• High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills.
• Passion for data analysis, solving technical problems and applying new technologies to further scientific goals.

Key Leadership Competencies:

• Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance.
• Learns fast and can change course quickly.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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