Neurocrine Biosciences
Sr. Principal Scientist, Antibody Engineering
Neurocrine Biosciences, San Diego, California, United States, 92189
Who We Are:
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do:
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders. For more information, visit
neurocrine.com , and follow the company on
LinkedIn ,
X (Formerly Twitter)
and
Facebook . (*in collaboration with AbbVie) About the Role: The Sr. Principal Scientist/Assoc. Director, Antibody Engineering will lead laboratory activities related to antibody engineering including library construction, affinity optimization, and developability engineering. The ideal candidate will have extensive hands-on experience and a proven track record in therapeutic antibody optimization, in a biotechnology or pharmaceutical company setting. The person in this role will support early-mid stage protein engineering in all therapeutic areas of Neurocrine’s biotherapeutic pipeline. Your Contributions (include, but are not limited to):
Drive therapeutic pipeline progression from discovery to lead selection within a cutting-edge antibody engineering team. Lead protein engineer responsible for all aspects of construct design, molecular cloning, multi-piece DNA assembly, site-directed mutagenesis, and preparation of libraries. Generate and screen site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization. Characterize antibodies and antibody-based therapeutics (e.g. affinity, specificity, cross-species binding, epitope determination). Engineer advanced modalities such as multi-specific antibodies and antibody conjugates. Design and clone antigens for immunization and screening. Utilize structural modeling software such as PyMol or MOE to mitigate developability issues. Understand experimental data from multiple sources, form hypotheses, devise strategies, and implement prioritization to drive projects. Evaluate emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation, and technologies related to antibody engineering. Work cross-functionally with protein biochemists, cell biologists, and gene therapists to achieve project goals. Other duties as assigned. Requirements:
PhD in Molecular Biology, Biochemistry, or other relevant discipline and 15+ years of relevant experience in the Biopharma industry. Knowledgeable in antibody structure/function including developability screening, effector function, half-life extension strategies, immunogenicity assessment, and bispecific formats. Hands-on experience in antibody optimization campaigns using directed evolution screening platforms. Demonstrated mastery of standard molecular biology bench skills, DNA sequence analysis, and oligo design. Experience building, training, and leading a team of productive bench scientists. Experience with standard laboratory instrumentation: PCR, centrifugation, DNA quantitation, gel documentation systems, plate readers and washers, liquid handling, etc. Familiarity with affinity determination methods (e.g. ELISA, MSD, Octet, Carterra, Biacore, or Kinexa). Ability to maintain detailed experimental documentation using Benchling. Excellent communication and interpersonal skills with an ability to work both independently and in a team environment. Proficiency in Microsoft Office and DNA sequence analysis software. Experience with various antibody formats including Fab, scFv, IgG, nanobody, conjugates, and multi-specific derivatives. Knowledge of standard antibody assay and cloning reagents and preferred vendors. Experience working with CROs for antibody discovery, expression, purification, and characterization. Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $150,700.00-$218,500.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
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At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options. What We Do:
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders. For more information, visit
neurocrine.com , and follow the company on
LinkedIn ,
X (Formerly Twitter)
and
Facebook . (*in collaboration with AbbVie) About the Role: The Sr. Principal Scientist/Assoc. Director, Antibody Engineering will lead laboratory activities related to antibody engineering including library construction, affinity optimization, and developability engineering. The ideal candidate will have extensive hands-on experience and a proven track record in therapeutic antibody optimization, in a biotechnology or pharmaceutical company setting. The person in this role will support early-mid stage protein engineering in all therapeutic areas of Neurocrine’s biotherapeutic pipeline. Your Contributions (include, but are not limited to):
Drive therapeutic pipeline progression from discovery to lead selection within a cutting-edge antibody engineering team. Lead protein engineer responsible for all aspects of construct design, molecular cloning, multi-piece DNA assembly, site-directed mutagenesis, and preparation of libraries. Generate and screen site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization. Characterize antibodies and antibody-based therapeutics (e.g. affinity, specificity, cross-species binding, epitope determination). Engineer advanced modalities such as multi-specific antibodies and antibody conjugates. Design and clone antigens for immunization and screening. Utilize structural modeling software such as PyMol or MOE to mitigate developability issues. Understand experimental data from multiple sources, form hypotheses, devise strategies, and implement prioritization to drive projects. Evaluate emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation, and technologies related to antibody engineering. Work cross-functionally with protein biochemists, cell biologists, and gene therapists to achieve project goals. Other duties as assigned. Requirements:
PhD in Molecular Biology, Biochemistry, or other relevant discipline and 15+ years of relevant experience in the Biopharma industry. Knowledgeable in antibody structure/function including developability screening, effector function, half-life extension strategies, immunogenicity assessment, and bispecific formats. Hands-on experience in antibody optimization campaigns using directed evolution screening platforms. Demonstrated mastery of standard molecular biology bench skills, DNA sequence analysis, and oligo design. Experience building, training, and leading a team of productive bench scientists. Experience with standard laboratory instrumentation: PCR, centrifugation, DNA quantitation, gel documentation systems, plate readers and washers, liquid handling, etc. Familiarity with affinity determination methods (e.g. ELISA, MSD, Octet, Carterra, Biacore, or Kinexa). Ability to maintain detailed experimental documentation using Benchling. Excellent communication and interpersonal skills with an ability to work both independently and in a team environment. Proficiency in Microsoft Office and DNA sequence analysis software. Experience with various antibody formats including Fab, scFv, IgG, nanobody, conjugates, and multi-specific derivatives. Knowledge of standard antibody assay and cloning reagents and preferred vendors. Experience working with CROs for antibody discovery, expression, purification, and characterization. Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $150,700.00-$218,500.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
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