Guardant Health
Bioinformatics Scientist II
Guardant Health, San Diego, California, United States, 92189
Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum.
Job Description
About the Role: The Bioinformatics Scientist II will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based transcript expression and methylation data integrated with epigenetic data sets. Essential Duties and Responsibilities: Work with large, complex data sets. Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data. Development, continuous improvement, and validations of novel biomarkers for Guardant Health oncology products. Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies. Work with the Technology Development team to develop and analyze verification and validation experiments as part of regulatory submissions. Provide analytic support on individual samples and research activities. Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency. Communicate research results through presentations and project reports as well as scientific publications. Qualifications
Ph.D. in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science. 1-3 years of experience. Proven scientific reputation as demonstrated by scientific publication and/or contribution to successful product development in the biotech industry. Deep understanding of modern tools and pipelines in genomics for processing and analysis of primary data, including somatic and structural variant calling. Experience with next generation sequencing data analysis (DNA, RNA, or epigenetic analysis). Deep experience with a statistical programming language (e.g., R, Python). Demonstrated effective written and verbal communication skills. Additional Information
Hybrid Work Model
: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $124,200 to $167,700. The range does not include benefits, and if applicable, bonus, commission, or equity. The US base salary range for this full-time position is $93,200 to $149,100. The range does not include benefits, and if applicable, bonus, commission, or equity. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com. Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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About the Role: The Bioinformatics Scientist II will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based transcript expression and methylation data integrated with epigenetic data sets. Essential Duties and Responsibilities: Work with large, complex data sets. Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data. Development, continuous improvement, and validations of novel biomarkers for Guardant Health oncology products. Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies. Work with the Technology Development team to develop and analyze verification and validation experiments as part of regulatory submissions. Provide analytic support on individual samples and research activities. Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency. Communicate research results through presentations and project reports as well as scientific publications. Qualifications
Ph.D. in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Cancer Biology, Genetics, Genomics, Computer Science. 1-3 years of experience. Proven scientific reputation as demonstrated by scientific publication and/or contribution to successful product development in the biotech industry. Deep understanding of modern tools and pipelines in genomics for processing and analysis of primary data, including somatic and structural variant calling. Experience with next generation sequencing data analysis (DNA, RNA, or epigenetic analysis). Deep experience with a statistical programming language (e.g., R, Python). Demonstrated effective written and verbal communication skills. Additional Information
Hybrid Work Model
: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $124,200 to $167,700. The range does not include benefits, and if applicable, bonus, commission, or equity. The US base salary range for this full-time position is $93,200 to $149,100. The range does not include benefits, and if applicable, bonus, commission, or equity. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com. Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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