Radionetics Oncology, Inc.
Senior Director, Biology (proteomics)
Radionetics Oncology, Inc., San Diego, California, United States, 92189
About Radionetics
Radionetics Oncology, Inc. is a clinical stage company focused on the discovery and development of novel radiopharmaceuticals for the treatment of a wide range of oncology indications and is poised to capitalize on the increasing demand for novel radiotherapeutics. Radionetics Oncology is supported by Frazier Life Sciences, 5AM Ventures, DCVC Bio, Crinetics Pharmaceuticals, and GordonMD Global Investments and has entered into a strategic agreement with Eli Lilly. Radionetics is advancing a pipeline of first-in-class small molecule radioligands targeting G protein coupled receptors for the treatment of a broad range of cancers, including breast cancer, lung cancer, and other indications of high unmet need. For more information, visit
radionetics.com .
Position summary The Senior Director, Biology (SrDir) is a dynamic and hands-on leader of the proteomic efforts that support the target identification and validation for the development of radiopharmaceuticals for solid tumors with high unmet need. The SrDir is the leader and technical expert in quantitative proteomics using mass spectrometry and has working knowledge of other orthogonal techniques for target validation (e.g. transcriptomics, Western blotting, etc.). The SrDir drives the strategy, oversees all activities within the proteomics group, and leads a team of highly skilled scientists with diverse skill sets. The SrDir is a key member of the team presenting results and participating in cross-functional groups to develop innovative solutions that drive multiple discovery programs forward in parallel.
Essential job functions and duties Provide strategic direction and technical leadership in mass spectrometry-based proteomics and other non-antibody-based methods of target validation. Oversee design and execution of proteomics experimentation to analyze protein expression, protein modification, and interactions using techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), shotgun proteomics, and targeted proteomics. Oversee development and optimization of experimental protocols for membrane protein extraction, purification, and quantification from a variety of biological samples (e.g. fresh frozen and FFPE tissues, cells, serum). Perform in-depth analysis and critical oversight of complex proteomics data, including protein identification, quantification, and post-translational modifications, using bioinformatics tools and software (e.g. DIA-NN, Spectronaut, MaxQuant, MS Fragger, Skyline, R, Python, Perseus, etc.). Oversee maintenance and troubleshooting of laboratory equipment, mass spectrometry and nano-HPLC systems. Prepare and present data reports and presentations to cross-functional teams and leadership. Recruit, coach, and retain scientists with a broad range of skills, fostering professional growth and creating a collaborative and dynamic work environment. Perform other responsibilities as required by business needs. Minimum required qualifications Ph.D. in Proteomics, Biochemistry, Molecular Biology, or a related field, or a Master’s degree with relevant and equivalent experience. Minimum 12 years of related experience with Ph.D. and 16 years with Master’s degree. Extensive and deep expertise with mass spectrometry-based proteomics instrumentation, in particular Bruker timsTOF and timsTOF Ultra systems. Experience on data-independent acquisition (DIA) and data-dependent acquisition (DDA) with emphasis on previous and demonstrated significant experience with DIA data. Experience with proximity-labeling mass spectrometry (BioID, TurboID), affinity purification mass spectrometry (AP-MS) and cross-linking mass spectrometry (XL-MS) are a plus. Demonstrated proficiency in the analysis of large proteomics datasets, bioinformatics software, and statistical and visualization tools. Advanced knowledge of software for data processing and database crunching (e.g., DIA_NN or Spectronaut, MaxQuant or MSFragger, Skyline) and rigorous data organizational skills to manage large data sets across multiple projects. Advanced knowledge of software for data analysis, statistical analysis and visualization (R, Python, Perseus) used together with deep understanding of target biology to generate actionable proteomic data. Strong knowledge of membrane protein biology, including protein modifications (e.g. glycosylation, phosphorylation, ubiquitination), protein-protein interactions, and protein structure-function relationships. Experience with laboratory techniques such as membrane protein purification, immunoprecipitation, and Western blotting. Excellent problem-solving, organizational, and analytical skills. Strong written and verbal communication skills, with the ability to effectively collaborate across teams. Ability to work independently and manage multiple projects simultaneously. Non-standard work schedule, travel or environmental requirements The position is based on-site in San Diego, CA.
Compensation & Benefits Radionetics has a competitive total compensation package that includes bonus opportunity; equity; medical, dental, vision, life, short-term, and long-term disability insurance; 401(k) retirement plan; 4 weeks of paid time off (PTO) annually; and generous paid holidays.
Pay Range:
$240,500 - $285,000 Radionetics evaluates a variety of factors in determining individual pay decisions, which may include relevant education, experience, and skills; internal equity; complexity and responsibility of the role; and market demand relative to the position. Geographic location may also be a consideration in evaluating salary when candidates work in states outside of California.
Important notices Radionetics Oncology, Inc. is committed to a policy of equal opportunity in which all qualified applicants receive equal consideration for employment without regard to race, color, national origin, ancestry, religion, sex, pregnancy, marital status, sexual orientation, gender, gender identity and expression, age, physical and medical disability, medical condition, genetic information, military or veteran status, or any other federal, state or local protected class.
The job description specifics provided above are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities and requirements. Radionetics retains the right to add or change duties, education, experience, skills or any other requirements of the position at any time.
Radionetics does not accept unsolicited referrals from employment agencies for position vacancies unless written authorization is provided from the Human Resources department before any candidates are referred for specific identified positions. In the absence of such written authorization, any actions taken by the employment business/agency shall be deemed to have been performed without consent or contractual agreement, and Radionetics shall not be liable for any fees arising from such actions or referrals for position vacancies at Radionetics.
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radionetics.com .
Position summary The Senior Director, Biology (SrDir) is a dynamic and hands-on leader of the proteomic efforts that support the target identification and validation for the development of radiopharmaceuticals for solid tumors with high unmet need. The SrDir is the leader and technical expert in quantitative proteomics using mass spectrometry and has working knowledge of other orthogonal techniques for target validation (e.g. transcriptomics, Western blotting, etc.). The SrDir drives the strategy, oversees all activities within the proteomics group, and leads a team of highly skilled scientists with diverse skill sets. The SrDir is a key member of the team presenting results and participating in cross-functional groups to develop innovative solutions that drive multiple discovery programs forward in parallel.
Essential job functions and duties Provide strategic direction and technical leadership in mass spectrometry-based proteomics and other non-antibody-based methods of target validation. Oversee design and execution of proteomics experimentation to analyze protein expression, protein modification, and interactions using techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), shotgun proteomics, and targeted proteomics. Oversee development and optimization of experimental protocols for membrane protein extraction, purification, and quantification from a variety of biological samples (e.g. fresh frozen and FFPE tissues, cells, serum). Perform in-depth analysis and critical oversight of complex proteomics data, including protein identification, quantification, and post-translational modifications, using bioinformatics tools and software (e.g. DIA-NN, Spectronaut, MaxQuant, MS Fragger, Skyline, R, Python, Perseus, etc.). Oversee maintenance and troubleshooting of laboratory equipment, mass spectrometry and nano-HPLC systems. Prepare and present data reports and presentations to cross-functional teams and leadership. Recruit, coach, and retain scientists with a broad range of skills, fostering professional growth and creating a collaborative and dynamic work environment. Perform other responsibilities as required by business needs. Minimum required qualifications Ph.D. in Proteomics, Biochemistry, Molecular Biology, or a related field, or a Master’s degree with relevant and equivalent experience. Minimum 12 years of related experience with Ph.D. and 16 years with Master’s degree. Extensive and deep expertise with mass spectrometry-based proteomics instrumentation, in particular Bruker timsTOF and timsTOF Ultra systems. Experience on data-independent acquisition (DIA) and data-dependent acquisition (DDA) with emphasis on previous and demonstrated significant experience with DIA data. Experience with proximity-labeling mass spectrometry (BioID, TurboID), affinity purification mass spectrometry (AP-MS) and cross-linking mass spectrometry (XL-MS) are a plus. Demonstrated proficiency in the analysis of large proteomics datasets, bioinformatics software, and statistical and visualization tools. Advanced knowledge of software for data processing and database crunching (e.g., DIA_NN or Spectronaut, MaxQuant or MSFragger, Skyline) and rigorous data organizational skills to manage large data sets across multiple projects. Advanced knowledge of software for data analysis, statistical analysis and visualization (R, Python, Perseus) used together with deep understanding of target biology to generate actionable proteomic data. Strong knowledge of membrane protein biology, including protein modifications (e.g. glycosylation, phosphorylation, ubiquitination), protein-protein interactions, and protein structure-function relationships. Experience with laboratory techniques such as membrane protein purification, immunoprecipitation, and Western blotting. Excellent problem-solving, organizational, and analytical skills. Strong written and verbal communication skills, with the ability to effectively collaborate across teams. Ability to work independently and manage multiple projects simultaneously. Non-standard work schedule, travel or environmental requirements The position is based on-site in San Diego, CA.
Compensation & Benefits Radionetics has a competitive total compensation package that includes bonus opportunity; equity; medical, dental, vision, life, short-term, and long-term disability insurance; 401(k) retirement plan; 4 weeks of paid time off (PTO) annually; and generous paid holidays.
Pay Range:
$240,500 - $285,000 Radionetics evaluates a variety of factors in determining individual pay decisions, which may include relevant education, experience, and skills; internal equity; complexity and responsibility of the role; and market demand relative to the position. Geographic location may also be a consideration in evaluating salary when candidates work in states outside of California.
Important notices Radionetics Oncology, Inc. is committed to a policy of equal opportunity in which all qualified applicants receive equal consideration for employment without regard to race, color, national origin, ancestry, religion, sex, pregnancy, marital status, sexual orientation, gender, gender identity and expression, age, physical and medical disability, medical condition, genetic information, military or veteran status, or any other federal, state or local protected class.
The job description specifics provided above are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities and requirements. Radionetics retains the right to add or change duties, education, experience, skills or any other requirements of the position at any time.
Radionetics does not accept unsolicited referrals from employment agencies for position vacancies unless written authorization is provided from the Human Resources department before any candidates are referred for specific identified positions. In the absence of such written authorization, any actions taken by the employment business/agency shall be deemed to have been performed without consent or contractual agreement, and Radionetics shall not be liable for any fees arising from such actions or referrals for position vacancies at Radionetics.
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