Clinical Research Assistant, Center for Clinical Investigation, Hybrid

PRINCIPAL DUTIES AND RESPONSIBILITIES: Lead experiments using advanced tissue-based imaging techniques, such as CyCIF and Orion multiplexed immunofluorescence assays, to investigate tumors. This work will involve collaborating closely with post-doctoral fellows and research scientists to define the direction and objectives of the projects and to develop large-scale public resources to support the wider research community. Design and optimize antibody panels, apply them to mouse models and patient samples, and analyze high-dimensional imaging data to uncover new insights into tumor biology. Implement methods such as spatial transcriptomics to generate multi-modal datasets, aimed at revealing mechanisms of drug response and potential new therapeutic targets. Present research findings at lab and group meetings and engage in weekly collaborative data review sessions. Help support routine lab maintenance tasks such as ordering supplies, maintaining equipment, and ensuring adherence to lab safety protocols. Assist with training new lab members in imaging techniques, data analysis tools, and molecular biology methods, fostering a collaborative learning environment. Stay up-to-date with relevant literature to inform experimental design and propose new approaches to address research challenges. Troubleshoot experimental issues, optimize protocols, and suggest improvements to enhance the quality and efficiency of ongoing projects. Collaborate with computational biologists to integrate imaging data with analytical pipelines, contributing to the generation of insights that support clinical trial design. Prepare and contribute to scientific publications, supporting the communication of research findings to the scientific community. QUALIFICATIONS: A motivated, intellectually curious individual with a Bachelor of Science degree in a quantitative field such as biomedical engineering. Someone ready to commit to a two-year position and eager to grow in a dynamic research environment. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: Experience in microscopy, quantitative biology, and data science is highly valued. Proficiency with tools for quantitative image analysis MATLAB, Python, and ImageJ is preferred. Strong communication skills and the ability to work both independently and collaboratively within a multidisciplinary team is required. WORKING CONDITIONS: General fast-paced office, clinical, and laboratory environment. Candidate may be required to work in multiple locations within the hospital. The candidate will be required to handle biological specimens and follow universal precautions for blood and pathogen protection. He/she will also handle various pieces of electronic equipment. Some heavy lifting and/or transporting may be necessary from time to time. Additional Job Description: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

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