Capricor Inc
Sr. Scientist, Nucleic Acid Delivery & InVitro Assay Development
Capricor Inc, San Diego, California, United States, 92189
Capricor Therapeutics is a biotechnology company dedicated to developing transformative therapies for rare diseases, with a primary focus on Duchenne muscular dystrophy (DMD). We are pioneers in cell therapy and exosome-based technology, leveraging our proprietary StealthX platform to engineer innovative treatments. Our team is committed to harnessing cutting-edge science and advanced technologies to meet the unmet needs of patients living with DMD and other challenging medical conditions. Join us on our journey as we push the boundaries of medical science and pave the way for a healthier future.
About the Role
We are seeking a highly motivated and skilled scientist with expertise in nucleic acid delivery to join our team as a Scientist/Senior Scientist, Nucleic Acid Delivery and In Vitro Assay Development. The successful candidate will lead efforts in designing, optimizing, and characterizing nucleic acid delivery platforms for therapeutic applications. This role involves close collaboration with cross-functional teams in molecular biology, cell biology, and pharmacology.
Responsibilities:
Nucleic Acid Delivery:
Develop and optimize nucleic acid (siRNA, PMO, ASO) delivery protocols using electroporation or similar techniques. Characterize the loading efficiency, stability, and activity of nucleic acids in delivery vehicles (e.g., exosomes, nanoparticles, or other carriers).
Cell Culture and Molecular Biology:
Maintain and manipulate primary and immortalized cell lines. Design and execute CRISPR-based gene editing experiments. Perform transfection, nucleic acid delivery, and downstream functional assays.
In Vitro Assay Development:
Design and validate in vitro assays to assess the efficacy and safety of nucleic acid therapeutics. Develop and execute PK/PD assays in vitro to characterize therapeutic candidates.
Data Analysis and Reporting:
Analyze experimental results, interpret data, and present findings to internal and external stakeholders. Document experimental protocols and results following standard scientific practices.
Collaboration and Innovation:
Work collaboratively with cross-functional teams to align experimental designs with project goals. Stay up-to-date with advancements in nucleic acid therapeutics, delivery technologies, and in vitro assay development.
Requirements: Education: Ph.D. in Molecular Biology, Biochemistry, Cell Biology, or a related field. Experience:
Hands-on experience with nucleic acid (siRNA, PMO, ASO) loading using electroporation or comparable techniques. Expertise in cell culture, including maintaining and manipulating various cell lines. Proven experience with CRISPR-based gene editing technologies. Demonstrated proficiency in developing and validating in vitro assays. Familiarity with PK/PD studies in vitro.
Preferred Qualifications:
Experience with advanced delivery systems (e.g., lipid nanoparticles, exosomes). iPSC or ESC culture and differentiation experience is preferred but not required. Strong analytical skills and experience with software tools for data analysis (e.g., GraphPad Prism, ImageJ). Knowledge of regulatory and safety requirements for therapeutic development.
Soft Skills:
Excellent organizational and multitasking skills. Strong written and verbal communication skills. Ability to work independently and in a team-oriented environment.
Work Environment / Physical Demands: This is a laboratory-based role with occasional requirements for data analysis and reporting. Must be able to sit and stand for extended periods. Must be able to lift/carry reports and materials up to 40 pounds, move about the office. Compensation (USD): Salary Range: $110,000-$120,000 This role offers competitive compensation based on experience and qualifications. Additional benefits include health insurance, retirement plans, and opportunities for professional development. Role Specific Location Policy: This role is based at our headquarters, with flexibility for remote work as needed. Occasional travel may be required for audits and regulatory inspections. Come work with us! Capricor Therapeutics is headquartered in San Diego, California. We offer competitive compensation and benefits, generous vacation and parental leave, flexible working hours, and a collaborative work environment.
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Develop and optimize nucleic acid (siRNA, PMO, ASO) delivery protocols using electroporation or similar techniques. Characterize the loading efficiency, stability, and activity of nucleic acids in delivery vehicles (e.g., exosomes, nanoparticles, or other carriers).
Cell Culture and Molecular Biology:
Maintain and manipulate primary and immortalized cell lines. Design and execute CRISPR-based gene editing experiments. Perform transfection, nucleic acid delivery, and downstream functional assays.
In Vitro Assay Development:
Design and validate in vitro assays to assess the efficacy and safety of nucleic acid therapeutics. Develop and execute PK/PD assays in vitro to characterize therapeutic candidates.
Data Analysis and Reporting:
Analyze experimental results, interpret data, and present findings to internal and external stakeholders. Document experimental protocols and results following standard scientific practices.
Collaboration and Innovation:
Work collaboratively with cross-functional teams to align experimental designs with project goals. Stay up-to-date with advancements in nucleic acid therapeutics, delivery technologies, and in vitro assay development.
Requirements: Education: Ph.D. in Molecular Biology, Biochemistry, Cell Biology, or a related field. Experience:
Hands-on experience with nucleic acid (siRNA, PMO, ASO) loading using electroporation or comparable techniques. Expertise in cell culture, including maintaining and manipulating various cell lines. Proven experience with CRISPR-based gene editing technologies. Demonstrated proficiency in developing and validating in vitro assays. Familiarity with PK/PD studies in vitro.
Preferred Qualifications:
Experience with advanced delivery systems (e.g., lipid nanoparticles, exosomes). iPSC or ESC culture and differentiation experience is preferred but not required. Strong analytical skills and experience with software tools for data analysis (e.g., GraphPad Prism, ImageJ). Knowledge of regulatory and safety requirements for therapeutic development.
Soft Skills:
Excellent organizational and multitasking skills. Strong written and verbal communication skills. Ability to work independently and in a team-oriented environment.
Work Environment / Physical Demands: This is a laboratory-based role with occasional requirements for data analysis and reporting. Must be able to sit and stand for extended periods. Must be able to lift/carry reports and materials up to 40 pounds, move about the office. Compensation (USD): Salary Range: $110,000-$120,000 This role offers competitive compensation based on experience and qualifications. Additional benefits include health insurance, retirement plans, and opportunities for professional development. Role Specific Location Policy: This role is based at our headquarters, with flexibility for remote work as needed. Occasional travel may be required for audits and regulatory inspections. Come work with us! Capricor Therapeutics is headquartered in San Diego, California. We offer competitive compensation and benefits, generous vacation and parental leave, flexible working hours, and a collaborative work environment.
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