POSTDOCTORAL FELLOWSHIP

DEPARTMENT OF DERMATOLOGY BRIGHAM AND WOMEN’S HOSPITAL HARVARD MEDICAL SCHOOL The Kupper laboratory in the Department of Dermatology at Brigham and Women’s Hospital (BWH) in Boston is seeking a post-doctoral fellow. We have made several fundamental advances in the characterization of how the tumor microenvironment suppresses the CD8 T cell response and how to overcome the suppression. Manipulation of cytokine activation of CD8 T cells, along with blocking cytokine activation of myeloid cell suppression, is central to our approach and relies on our ability to manipulate these molecules and their receptors in a unique way. Along with spatial profiling and molecular imaging, we are using engineered therapeutic molecules to tip the balance towards T cell activation in the tumor microenvironment. Our research utilizes both standard immunologic techniques (immunofluorescence/immunohistochemistry, microscopy, flow cytometry and sorting, in situ hybridization, western blot, etc.) and novel technologies (high-throughput TCR sequencing, nanostring analysis, single cell RNAseq, multispectral labeling and imaging of tissue, spatial profiling, and laser capture microscopy). We work with both human specimens and mouse models of disease. Highly motivated candidates with an M.D., Ph.D., or M.D./Ph.D. in Immunology or a related field are strongly encouraged to apply. Applicants should possess strong laboratory, analytical, interpersonal, and communication skills. The BWH Department of Dermatology is located in the Longwood Medical Area, which contains ten major institutions, including research-oriented hospitals, research institutes, Harvard Medical School, and the Harvard School of Public Health, providing a rich training environment. Interested candidates should email a brief cover letter indicating their research interests and career goals, CV, and contact information for three references to: Thomas Kupper, M.D. Brigham and Women’s Hospital Department of Dermatology 77 Ave. Louis Pasteur, HIM660 Boston, MA 02115 Attn:

Matthew Opperman; MOPPERMAN@BWH.HARVARD.EDU An Equal Opportunity / Affirmative Action Employer.

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