About Codify Therapeutics
Codify Therapeutics is an innovative startup committed to leveraging alternative splicing to discover transformational medicines. Our mission is to develop groundbreaking treatments that address unmet medical needs and improve the lives of patients. Leveraging cutting-edge technologies from world-renowned scientific founders, Codify is dedicated to pushing the boundaries of cancer research and treatment.
Job Description
As a Scientist at Codify Therapeutics, you will play a key role in our growing organization, both to meet R&D needs and to drive projects in the Platform and Target Discovery group. This position offers a unique opportunity to collaborate with cross-functional teams and be a part of the early scientific team building a new and exciting therapeutic modality.
Responsibilities
- Design and perform cell-based models and develop assays for new therapeutic target discovery
- Techniques may include CRISPR and/or lentivirus based genetic manipulation, and the development of fluorescent or luminescent reporters
- Design and execute experiments for therapeutic target and hit identification using a combination of molecular, cellular, genetics, and functional genomics skills
- Techniques may include mammalian cell culture, RT-PCR, qPCR, Western blot, flow analysis, cellular assays (viability, death, dose response), and genetic perturbation using ASOs, siRNAs, shRNAs, CRISPR
- Design and execute high throughput screens, as well as downstream data analysis
- Execute experiments and analysis diligently to yield meaningful results - Interpret data thoughtfully - Identify potential pitfalls and obstacles and overcome them - Communicate with clarity on timelines and research plans
- Collaborate with cross functional teams and support training of junior researchers
- Other research skills: Data analysis and visualization - Maintain clear and detailed electronic notebook - Communicate findings and results at internal meetings
Qualifications
- PhD degree in biology, molecular biology, genomics, or related science and relevant research experience
- Experience with experimental or computational research in functional genomics or RNA biology is a plus, as well as experience with MPRA or CRISPR screens and AmpliconSeq analysis