Postdoctoral Fellow Scientist - Immunobiology Discovery

Job Description Who We Are EvolveImmune Therapeutics is a next- immunotherapy company pioneering a new class of T cell engager therapies to transform patient outcomes compared to current therapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable, tissue-localized anti-tumor adaptive immune responses. Our newly expanded, state-of-the-art 16,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor, together with in vivo pharmacology laboratories in Farmington, CT, support in-house biologic discovery, immunobiology, manufacturing support, and translational activities which have enabled our rapid pipeline progress. This includes the development of EVOLVE104, our lead solid tumor program, which is rapidly advancing toward IND filing. The Role We are seeking a highly motivated and creative postdoctoral fellow to join our Immunobiology group. The position represents a unique opportunity to leverage basic immunology concepts to design and test novel immunotherapies. The successful candidate will contribute to the development of innovative immunotherapeutic modalities to target T cells to tumors and promote anti-tumor immunity. Molecular and cellular immunology concepts will be used to guide the experimental design process as well as the approaches to test and refine the novel platform features. The candidate will be responsible for designing and performing

in vitro

functional assays to test protein designs based on tumor killing potency, cytokine release, and immune modulatory mechanism of action. We are looking for a candidate who thrives in a collaborative, team-oriented environment and is eager to leverage the growth opportunities within a matrixed organization. This is an exceptional opportunity for a passionate scientist to embrace drug discovery and translate innovative immunology research into novel therapeutics. Responsibilities This laboratory-based position within the immunobiology group will work closely with our immunobiology and protein engineering colleagues to design and execute functional

ex vivo

studies to evaluate novel protein therapeutics to guide data-driven platform innovations decisions. Design and execute experiments focused on functional tumor-immune co-culture assays and phenotypic assessments of T cell engager-driven immune cell response to identify outcomes associated with protein design features and define mechanism of differentiation. Emphasis will be placed on publication in peer-reviewed scientific journals and patent inventorship. Keep detailed records of experiments in electronic notebooks, analyze data, prepare and deliver high quality presentations to research team members. Qualifications PhD in immunology, cell and molecular biology, biochemistry, pharmacology, or related discipline recently completing doctoral studies. Proven ability to delineate and implement successful research projects as demonstrated by a strong publication record. Expertise in immune cell biology techniques that include multi-flow cytometry immune cell profiling, single cell RNAseq and experience with the focused analysis of T cell subsets. Strong interpersonal skills to support problem-solving and delivery in a team-oriented, collaborative environment. EvolveImmune Therapeutics requires all employees to be fully vaccinated against COVID-19. You may seek reasonable accommodations for medical and personal reasons. However, your application is no guarantee that such accommodations will be made available. EvolveImmune Therapeutics, Inc. is an equal opportunity employer. EvolveImmune provides competitive compensation and benefits package. For more information, please visit

https://www.evolveimmune.com/ .

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