Vertex Pharmaceuticals
Analytical Development Scientist - Cell & Gene Therapy
Vertex Pharmaceuticals, Boston, Massachusetts, us, 02298
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Analytical Development Scientist - Cell & Gene Therapy
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locations
Boston, MA
time type
Full time
posted on
Posted 30+ Days Ago
job requisition id
REQ-22064
Job DescriptionGeneral Summary:Vertex pharmaceuticals is seeking a research scientist to join the analytical development, cell and gene therapy team. This position is expected to serve as a key contributor in expanding our mass spectrometry characterization capabilities in proteomics for supporting cell and gene therapy program development. Extensive hands-on experience in liquid chromatography-mass spectrometry and proteomics is required. The individual in this role will collaborate closely with research, process development, manufacturing, regulatory, and quality to develop and innovate Vertex next generation Cell and Gene Therapy products.Key Duties and Responsibilities:Provide hands-on support for mass spectrometry-based proteomics characterization and perform biological pathway analysis.Conduct proteomics experiments on different cell types (intracellular and cell surface) including but not limited to stem cells, differentiated cells, single cell.Use state-of-art LC-MS platforms (Orbitrap, Q-ToF, QQQ, etc.) coupled with different front-end chromatographic separation techniques (reverse phase, HILIC, ion exchange, size exclusion, etc.) to advance Vertex’s pipeline molecules.Provide expertise in experimental design, data analysis, assay trouble shooting, technical report writing, and presentations.Author analytical method, qualification, and validation reports.Maintain proper documentations of experimental results and data interpretations.Ensure data quality and maintain data integrity of analytical results to support decision making.Collaborate with research and process development teams to develop fit for purpose analytical characterization methods for target optimization, product characterization and product investigations.Knowledge and Skills:Strong hands-on experience on LC-MS based proteomics analysis and Orbitrap mass spectrometers is required.Strong hands-on experience with advanced proteomics sample preparation techniques for protein isolation from cells, sub-cellular fractionation, immuno- or chemical affinity purification is required.Strong hands-on experience with label free and TMT based multiplex quantification is required.Experience with multi-omics and statistical analysis poises additional value.Demonstrated capabilities to independently digest and formulate experimental conclusions by referencing orthogonal analytical results.Ability to use information gained from experiments to inform method and program decisions.Skilled in efficient study design and demonstrated expertise in writing SOPs, analytical protocols and reports.Ability to multi-task as necessary, managing competing priorities, and advancing multiple projects within required timelines.Demonstrated ability to work cross-functionally to improve communication, strong track record in cross-team collaboration.Strong oral & written communication skills.Education and Experience:Typically requires the following, or the equivalent combination of education and experience: PhD (0-2 years), or Master's (4+ years), or Bachelor's (6+ years) relevant experience in biopharmaceutical industry.#LI-onsite #LI-SV1Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at
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Posted 30+ Days AgoVertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and
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beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency
.Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit
www.vrtx.com
or follow us on
Facebook
,
Twitter/X
,
LinkedIn
,
YouTube
and
Instagram
.The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.
#J-18808-Ljbffr
Analytical Development Scientist - Cell & Gene Therapy
Apply
locations
Boston, MA
time type
Full time
posted on
Posted 30+ Days Ago
job requisition id
REQ-22064
Job DescriptionGeneral Summary:Vertex pharmaceuticals is seeking a research scientist to join the analytical development, cell and gene therapy team. This position is expected to serve as a key contributor in expanding our mass spectrometry characterization capabilities in proteomics for supporting cell and gene therapy program development. Extensive hands-on experience in liquid chromatography-mass spectrometry and proteomics is required. The individual in this role will collaborate closely with research, process development, manufacturing, regulatory, and quality to develop and innovate Vertex next generation Cell and Gene Therapy products.Key Duties and Responsibilities:Provide hands-on support for mass spectrometry-based proteomics characterization and perform biological pathway analysis.Conduct proteomics experiments on different cell types (intracellular and cell surface) including but not limited to stem cells, differentiated cells, single cell.Use state-of-art LC-MS platforms (Orbitrap, Q-ToF, QQQ, etc.) coupled with different front-end chromatographic separation techniques (reverse phase, HILIC, ion exchange, size exclusion, etc.) to advance Vertex’s pipeline molecules.Provide expertise in experimental design, data analysis, assay trouble shooting, technical report writing, and presentations.Author analytical method, qualification, and validation reports.Maintain proper documentations of experimental results and data interpretations.Ensure data quality and maintain data integrity of analytical results to support decision making.Collaborate with research and process development teams to develop fit for purpose analytical characterization methods for target optimization, product characterization and product investigations.Knowledge and Skills:Strong hands-on experience on LC-MS based proteomics analysis and Orbitrap mass spectrometers is required.Strong hands-on experience with advanced proteomics sample preparation techniques for protein isolation from cells, sub-cellular fractionation, immuno- or chemical affinity purification is required.Strong hands-on experience with label free and TMT based multiplex quantification is required.Experience with multi-omics and statistical analysis poises additional value.Demonstrated capabilities to independently digest and formulate experimental conclusions by referencing orthogonal analytical results.Ability to use information gained from experiments to inform method and program decisions.Skilled in efficient study design and demonstrated expertise in writing SOPs, analytical protocols and reports.Ability to multi-task as necessary, managing competing priorities, and advancing multiple projects within required timelines.Demonstrated ability to work cross-functionally to improve communication, strong track record in cross-team collaboration.Strong oral & written communication skills.Education and Experience:Typically requires the following, or the equivalent combination of education and experience: PhD (0-2 years), or Master's (4+ years), or Bachelor's (6+ years) relevant experience in biopharmaceutical industry.#LI-onsite #LI-SV1Company InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at
ApplicationAssistance@vrtx.com.Similar Jobs (5)
Analytical Development Principal Research Scientist - Cell & Gene Therapy
locations
Boston, MA
time type
Full time
posted on
Posted 10 Days Ago
Process Development Engineering Scientist - Cell Therapy
locations
Boston, MA
time type
Full time
posted on
Posted 30 Days Ago
Director, Regulatory CMC, Cell & Gene Therapy (Boston)
locations
Boston, MA
time type
Full time
posted on
Posted 30+ Days AgoVertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and
transfusion-dependent
beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency
.Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit
www.vrtx.com
or follow us on
,
Twitter/X
,
,
YouTube
and
.The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.
#J-18808-Ljbffr