Biogen, Inc.
Principal Associate Scientist, Translational Medicine, Biomarkers Imaging
Biogen, Inc., Cambridge, Massachusetts, us, 02140
Principal Associate Scientist, Translational Medicine, Biomarkers Imaging
Full-timeRegion: USDepartment: Research & DevelopmentAbout This RoleBiogen’s Translational Medicine Biomarkers Imaging group is actively engaged in an innovative and dynamic molecular imaging research program which includes the discovery and characterization of radiotracers and methodologies for application in drug development. We are seeking a results-oriented scientist with expertise in plate-based and tissue-based pharmacology techniques using radioligands in in-vitro and in-vivo biological systems. The role will be predominantly laboratory-based (80-90%), and will work closely with other Imaging team representatives as well as other program teams.What You’ll DoEvaluate the pharmacology of lead small molecules in-vitro and in-vivo in biological systems using different molecular imaging approachesUse radiolabeled molecules such as [3H] and [18F] to carry out molecular pharmacology assaysIn-vitro and ex-vivo radioligand binding for plate-based and autoradiographic brain imagingHuman and rodent tissue processing such as cryostat brain slicing and homogenate generation for protein target isolationAssay and method development of plate-based and ex-vivo brain imaging studiesAnimal handling including brain dissection and dosing with compounds or radioisotopesTarget identification techniques using IHC and immunofluorescencePresent data at team meetings and internal group forumsWho You AreA highly motivated, results-oriented scientist with strong communication skills who enjoys working in a collaborative environment. You’ll support a team of scientists in the preclinical discovery of novel Biomarker PET tracers for human clinical trials of neurological disorders.Required SkillsBachelor's degree with at least 4-6 years industry experience in pharma/biotech or CRO or Master's degree with at least 2-4 years industry experience in pharma/biotech or CROPlate-based pharmacology techniquesCompound handling and solution preparationsRadioisotope handlingAssay development and optimization experienceRodent animal handling and compound dosing, tissue dissectionFamiliarity with immunohistochemistry (IHC) techniques for target detection in brain slicesPreferred SkillsKnowledge of therapeutic areas in neurology (e.g. neurodegenerative diseases)Why Biogen?We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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Full-timeRegion: USDepartment: Research & DevelopmentAbout This RoleBiogen’s Translational Medicine Biomarkers Imaging group is actively engaged in an innovative and dynamic molecular imaging research program which includes the discovery and characterization of radiotracers and methodologies for application in drug development. We are seeking a results-oriented scientist with expertise in plate-based and tissue-based pharmacology techniques using radioligands in in-vitro and in-vivo biological systems. The role will be predominantly laboratory-based (80-90%), and will work closely with other Imaging team representatives as well as other program teams.What You’ll DoEvaluate the pharmacology of lead small molecules in-vitro and in-vivo in biological systems using different molecular imaging approachesUse radiolabeled molecules such as [3H] and [18F] to carry out molecular pharmacology assaysIn-vitro and ex-vivo radioligand binding for plate-based and autoradiographic brain imagingHuman and rodent tissue processing such as cryostat brain slicing and homogenate generation for protein target isolationAssay and method development of plate-based and ex-vivo brain imaging studiesAnimal handling including brain dissection and dosing with compounds or radioisotopesTarget identification techniques using IHC and immunofluorescencePresent data at team meetings and internal group forumsWho You AreA highly motivated, results-oriented scientist with strong communication skills who enjoys working in a collaborative environment. You’ll support a team of scientists in the preclinical discovery of novel Biomarker PET tracers for human clinical trials of neurological disorders.Required SkillsBachelor's degree with at least 4-6 years industry experience in pharma/biotech or CRO or Master's degree with at least 2-4 years industry experience in pharma/biotech or CROPlate-based pharmacology techniquesCompound handling and solution preparationsRadioisotope handlingAssay development and optimization experienceRodent animal handling and compound dosing, tissue dissectionFamiliarity with immunohistochemistry (IHC) techniques for target detection in brain slicesPreferred SkillsKnowledge of therapeutic areas in neurology (e.g. neurodegenerative diseases)Why Biogen?We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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