Allen Spolden
Director or Associate Director, Medicinal Chemistry
Allen Spolden, La Jolla, California, us, 92093
Job DescriptionWe seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
KEY RESPONSIBILITIESLead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidatesDevise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principlesWork closely with molecular and cellular biology, pharmacology, computational chemistry,
ADME, and other key functionsAct as liaison between Entos, CROs, and other external partnersInfluence the prospective use of computational methods and leverage automated synthesis
and high-throughput experimentation capabilitiesWork closely with AI/ML teams to develop and implement relevant predictive models to aid
in the design of new moleculesCommunicate project updates clearly and effectively to the broader team and key
stakeholdersWork as a senior member of the Chemistry research group and foster a culture of scientific
excellence, innovation, and teamworkPREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discoveryExpert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patentsAbility to integrate multiple R&D disciplines into a successful strategic project planExperience in leading projects and driving programs through the preclinical development
processExperience working with computational chemists as part of project team in design of drug targets is requiredStrong interpersonal, communication, time management, and leadership skillsExperience mentoring or leading junior chemistsCreative problem solving and management of relationships with several stakeholders within
and beyond the company
RequirementsPREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discoveryExpert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patentsAbility to integrate multiple R&D disciplines into a successful strategic project planExperience in leading projects and driving programs through the preclinical development
processExperience working with computational chemists as part of project team in design of drug targets is requiredStrong interpersonal, communication, time management, and leadership skillsExperience mentoring or leading junior chemistsCreative problem solving and management of relationships with several stakeholders within
and beyond the company
Benefits
Dental, Medical, Vision and 401K
KEY RESPONSIBILITIESLead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidatesDevise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principlesWork closely with molecular and cellular biology, pharmacology, computational chemistry,
ADME, and other key functionsAct as liaison between Entos, CROs, and other external partnersInfluence the prospective use of computational methods and leverage automated synthesis
and high-throughput experimentation capabilitiesWork closely with AI/ML teams to develop and implement relevant predictive models to aid
in the design of new moleculesCommunicate project updates clearly and effectively to the broader team and key
stakeholdersWork as a senior member of the Chemistry research group and foster a culture of scientific
excellence, innovation, and teamworkPREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discoveryExpert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patentsAbility to integrate multiple R&D disciplines into a successful strategic project planExperience in leading projects and driving programs through the preclinical development
processExperience working with computational chemists as part of project team in design of drug targets is requiredStrong interpersonal, communication, time management, and leadership skillsExperience mentoring or leading junior chemistsCreative problem solving and management of relationships with several stakeholders within
and beyond the company
RequirementsPREFERRED QUALIFICATIONS
A Ph.D./Postdoc in organic chemistry with 8 or more years of experience in Pharma/Bio-tech drug discoveryExpert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patentsAbility to integrate multiple R&D disciplines into a successful strategic project planExperience in leading projects and driving programs through the preclinical development
processExperience working with computational chemists as part of project team in design of drug targets is requiredStrong interpersonal, communication, time management, and leadership skillsExperience mentoring or leading junior chemistsCreative problem solving and management of relationships with several stakeholders within
and beyond the company
Benefits
Dental, Medical, Vision and 401K