Flagship Pioneering
Pioneering Medicines | Cambridge, MA Pioneering Medicines: Associate Director, E
Flagship Pioneering, Cambridge, Massachusetts, us, 02140
Pioneering Medicines: Associate Director, Explorations (Physician Scientist)
Cambridge, MA USAWhat if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need.Position Summary:Pioneering Medicines is seeking a curious, driven physician-scientist with both clinical and basic science experience to imagine and create transformative therapies enabled by Flagship’s broad array of novel platforms and technologies. This individual would report to the VP, Clinical Development and Leader, Explorations, Pioneering Medicines.The core accountability for this role is leading new product concept explorations. Explorations are the iterative hypothesis generation and refinement process that Flagship has used to create novel platforms. Pioneering Medicines has adapted this process to the development of new therapeutic product concepts. An Explorer must be facile at gathering, reviewing, and integrating information regarding a potential therapeutic across multiple domains, including epidemiology, pathobiology, existing treatments, genetics, *“omics”, biomarkers, in vitro and in vivo model systems and data, etc. The Explorer will work with a team that includes a project leader, scientist, and individuals experienced in the various aspects of clinical development, but is accountable for moving the exploration forward, including consultation with outside experts to refine hypotheses. When completed, the Explorer will participate in presenting the concept to key stakeholders.Individuals in this role will also be expected to provide clinical input as regards the challenges requiring solutions – the unmet need and the patient journey. Depending on experience, the individual would also contribute to clinical development plans including evaluation of trial designs, endpoints, and relevant regulatory guidance.Key Responsibilities:Participates in high impact, high profile product Explorations each year across therapeutic areas and diseases in context of Pioneering Medicines’ portfolio strategy.Imagines transformational clinical outcomes and proposes scope and objectives of each Exploration.Is accountable, working with a small team, to generate the greatest variation in product concepts as possible with unconstrained thinking.Proactively seeks to subject the diversity of our ideas to selection pressures. Is skilled in eliciting expert critiques of our product concepts that challenge the current dogma in that field.Defines precisely a few select product concepts at the end of the Exploration.Engages in a process with leadership of prioritizing the most compelling concepts that could become ProtoCos, Flagship’s first stage of development.Builds strong relationships across Flagship and the dozens of Flagship platform companies.Balances unconstrained, highly creative thinking with an Exploration Method designed to create product concepts with transformational clinical outcomes.Establishes a close partnering relationship with each team member and contributes to a high-energy team spirit.Minimum Qualifications:Medical Degree (MD or DO preferred).Basic scientific training (e.g., PhD or substantial research experience including peer-reviewed publications).Clinical training/experience, clinical development experience are a plus.Extremely resourceful and effective in highly uncertain circumstances.Strong prioritization skills.Able to quickly and adaptively acquire and synthesize information.Comfortable entering new space scientifically and clinically.Willing to consider unreasonable approaches to challenging problems.Effectively utilizes information technology systems and project management tools.Demonstrated ability to work well with others within and across functions/teams.Able to lead a team through a challenging exploration.Able to influence project team decisions and challenge team member recommendations.Strong communication skills both written and verbal; able to foster open communication.Ability to distill information and synthesize it into a coherent story for the audience.Values and BehaviorsEntrepreneurial spirit and mission-oriented towards breakthrough therapies.Courage to take bold risks to advance novel treatments.Ability to motivate and encourage colleagues at all levels.Fostering a growth-oriented, high-energy environment.Holding oneself and others accountable for commitments.WHAT WE OFFER:Impactful role in a company recognized for transformative contributions.Dynamic startup culture with inspiring colleagues and leaders.Support for groundbreaking advancements in healthcare and sustainability.Opportunities for professional growth in an innovative environment.Comprehensive employee benefits and rewards program.Join Pioneering Medicines and be part of a mission-driven organization dedicated to advancing human health and sustainability through scientific innovation.
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Cambridge, MA USAWhat if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need.Position Summary:Pioneering Medicines is seeking a curious, driven physician-scientist with both clinical and basic science experience to imagine and create transformative therapies enabled by Flagship’s broad array of novel platforms and technologies. This individual would report to the VP, Clinical Development and Leader, Explorations, Pioneering Medicines.The core accountability for this role is leading new product concept explorations. Explorations are the iterative hypothesis generation and refinement process that Flagship has used to create novel platforms. Pioneering Medicines has adapted this process to the development of new therapeutic product concepts. An Explorer must be facile at gathering, reviewing, and integrating information regarding a potential therapeutic across multiple domains, including epidemiology, pathobiology, existing treatments, genetics, *“omics”, biomarkers, in vitro and in vivo model systems and data, etc. The Explorer will work with a team that includes a project leader, scientist, and individuals experienced in the various aspects of clinical development, but is accountable for moving the exploration forward, including consultation with outside experts to refine hypotheses. When completed, the Explorer will participate in presenting the concept to key stakeholders.Individuals in this role will also be expected to provide clinical input as regards the challenges requiring solutions – the unmet need and the patient journey. Depending on experience, the individual would also contribute to clinical development plans including evaluation of trial designs, endpoints, and relevant regulatory guidance.Key Responsibilities:Participates in high impact, high profile product Explorations each year across therapeutic areas and diseases in context of Pioneering Medicines’ portfolio strategy.Imagines transformational clinical outcomes and proposes scope and objectives of each Exploration.Is accountable, working with a small team, to generate the greatest variation in product concepts as possible with unconstrained thinking.Proactively seeks to subject the diversity of our ideas to selection pressures. Is skilled in eliciting expert critiques of our product concepts that challenge the current dogma in that field.Defines precisely a few select product concepts at the end of the Exploration.Engages in a process with leadership of prioritizing the most compelling concepts that could become ProtoCos, Flagship’s first stage of development.Builds strong relationships across Flagship and the dozens of Flagship platform companies.Balances unconstrained, highly creative thinking with an Exploration Method designed to create product concepts with transformational clinical outcomes.Establishes a close partnering relationship with each team member and contributes to a high-energy team spirit.Minimum Qualifications:Medical Degree (MD or DO preferred).Basic scientific training (e.g., PhD or substantial research experience including peer-reviewed publications).Clinical training/experience, clinical development experience are a plus.Extremely resourceful and effective in highly uncertain circumstances.Strong prioritization skills.Able to quickly and adaptively acquire and synthesize information.Comfortable entering new space scientifically and clinically.Willing to consider unreasonable approaches to challenging problems.Effectively utilizes information technology systems and project management tools.Demonstrated ability to work well with others within and across functions/teams.Able to lead a team through a challenging exploration.Able to influence project team decisions and challenge team member recommendations.Strong communication skills both written and verbal; able to foster open communication.Ability to distill information and synthesize it into a coherent story for the audience.Values and BehaviorsEntrepreneurial spirit and mission-oriented towards breakthrough therapies.Courage to take bold risks to advance novel treatments.Ability to motivate and encourage colleagues at all levels.Fostering a growth-oriented, high-energy environment.Holding oneself and others accountable for commitments.WHAT WE OFFER:Impactful role in a company recognized for transformative contributions.Dynamic startup culture with inspiring colleagues and leaders.Support for groundbreaking advancements in healthcare and sustainability.Opportunities for professional growth in an innovative environment.Comprehensive employee benefits and rewards program.Join Pioneering Medicines and be part of a mission-driven organization dedicated to advancing human health and sustainability through scientific innovation.
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