Drug Hunter Inc.
Director
Drug Hunter Inc., Cambridge, Massachusetts, us, 02140
Third Harmonic Bio is a biopharmaceutical company with a singular purpose: To create a breakthrough treatment for people living with severe allergy and inflammation – debilitating conditions that can take a significant toll on overall health and well-being.We are developing a highly selective oral wild-type KIT inhibitor for millions of people living with chronic urticaria, severe asthma, and other mast cell-mediated diseases. Despite the availability of multiple approved medicines, there is an urgent need for new treatment options. We are grounded in our purpose of developing medicines to meaningfully improve the lives of the patients we serve.We are seeking smart, fun, and talented individuals seeking a fast-paced environment where they can meaningfully contribute to building a successful company.Our ValuesOur values provide the foundation for our culture and our operating principles – and underly how we hold ourselves accountable and how we interact with each other, with our partners, and with the global medical and patient community.Be HumanRelationships are important. Bring your full self to work and create space for others to do the same. Balance candor with empathy.Own the Big PictureContext is critical. Ground every decision and action in the entirety of what we are trying to achieve.Go THRDWe hold ourselves to a higher standard. Work with urgency, purpose, and passion.The RoleReporting to the Vice President, Chemistry, the
Director, Computational Chemistry , will play a critical role in program strategy, hit finding, compound design and prioritization, and drug optimization. This role is for an experienced drug hunting expert, who will apply advanced computational technologies to real-world molecular design. It is an exciting time to join Third Harmonic Bio and operate across the computational and medicinal chemistry fields to make our drug discovery engine faster as well as driving the exploration and implementation of AI/ML techniques to enhance the drug-discovery process.ResponsibilitiesCreate visual representations of molecular interactions, complete generative design and other forward-looking approaches to support structure-based drug designDesign compounds and predict their potency and ADMET using cutting-edge computational chemistry methods, including physics/ML based activity predictionCollaborate with cross-functional program teams in successful implementation of the strategy and execution of drug discovery programsLead the integration, and promote the use of, computational chemistry and cheminformatics methods to expedite the Design-Make-Test-Analyze discovery cyclePartner closely with our medicinal chemistry and biology teams in hit-finding initiatives and to provide timely compound design support to rationalize structural biology, chemical biology, and in vitro and in vivo SAR data driving towards drug candidate selectionInvestigate and analyze key challenges during hit and lead optimization processes to propose novel testable solutions and improve screening outcomesFoster data-informed culture; advise stakeholders in new target and druggability assessment by providing protein structure analysis, compound analysis, technical expertise, and constructive feedbackFacilitate effective decision-making throughout the target identification to candidate nomination process with the development of predictive models, simulations and validationUnderstand and advocate for emerging technologies and scientific advancements in computational chemistry, new tools and methodologiesRequired QualificationsPh.D. in Computational Chemistry, Computational Medicinal Chemistry or related field7-10+ years of experience in drug discovery with proven record in drug design / discovery principlesDemonstrated experience across commercial molecular modeling packages (e.g. Schrodinger, MOE, OpenEye, Pymol, Molsoft) and cheminformatics packages as well as experience in scientific scriptingSkilled in the application of ML in drug discovery, including application to generative molecular design and in property predictionStrong communication skills with the ability to convey complex messages, including effective ability to summarize and document data and resultsStrong scientific programming skills (e.g. Python, R) and pipelining tools, (e.g. Knime)The approximate salary range for this role is $194,000-$220,000.All qualified applicants will receive consideration for employment without regard to race, sex color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.Apply for this job
First Name * Last Name * Email * Phone * Resume/CV * Accepted file types: pdf, doc, docx, txt, rtfLinkedIn Profile Website Are you comfortable working in a hybrid setting? * Are you willing to undergo a background check, in accordance with local law/regulations? * Work Authorization: Are you legally authorized to work in the United States? *Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.Select...Voluntary Self-Identification of Disability
Form CC-305OMB Control Number 1250-0005 Expires 04/30/2026Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one.How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to:Alcohol or other substance use disorder (not currently using drugs illegally)Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDSBlind or low visionCancer (past or present)Cardiovascular or heart diseaseCeliac diseaseCerebral palsyDeaf or serious difficulty hearingDiabetesDisfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disordersEpilepsy or other seizure disorderGastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndromeIntellectual or developmental disabilityMental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSDMissing limbs or partially missing limbsMobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supportsNervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilitiesPartial or complete paralysis (any cause)Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysemaShort stature (dwarfism)Traumatic brain injuryPUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
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Director, Computational Chemistry , will play a critical role in program strategy, hit finding, compound design and prioritization, and drug optimization. This role is for an experienced drug hunting expert, who will apply advanced computational technologies to real-world molecular design. It is an exciting time to join Third Harmonic Bio and operate across the computational and medicinal chemistry fields to make our drug discovery engine faster as well as driving the exploration and implementation of AI/ML techniques to enhance the drug-discovery process.ResponsibilitiesCreate visual representations of molecular interactions, complete generative design and other forward-looking approaches to support structure-based drug designDesign compounds and predict their potency and ADMET using cutting-edge computational chemistry methods, including physics/ML based activity predictionCollaborate with cross-functional program teams in successful implementation of the strategy and execution of drug discovery programsLead the integration, and promote the use of, computational chemistry and cheminformatics methods to expedite the Design-Make-Test-Analyze discovery cyclePartner closely with our medicinal chemistry and biology teams in hit-finding initiatives and to provide timely compound design support to rationalize structural biology, chemical biology, and in vitro and in vivo SAR data driving towards drug candidate selectionInvestigate and analyze key challenges during hit and lead optimization processes to propose novel testable solutions and improve screening outcomesFoster data-informed culture; advise stakeholders in new target and druggability assessment by providing protein structure analysis, compound analysis, technical expertise, and constructive feedbackFacilitate effective decision-making throughout the target identification to candidate nomination process with the development of predictive models, simulations and validationUnderstand and advocate for emerging technologies and scientific advancements in computational chemistry, new tools and methodologiesRequired QualificationsPh.D. in Computational Chemistry, Computational Medicinal Chemistry or related field7-10+ years of experience in drug discovery with proven record in drug design / discovery principlesDemonstrated experience across commercial molecular modeling packages (e.g. Schrodinger, MOE, OpenEye, Pymol, Molsoft) and cheminformatics packages as well as experience in scientific scriptingSkilled in the application of ML in drug discovery, including application to generative molecular design and in property predictionStrong communication skills with the ability to convey complex messages, including effective ability to summarize and document data and resultsStrong scientific programming skills (e.g. Python, R) and pipelining tools, (e.g. Knime)The approximate salary range for this role is $194,000-$220,000.All qualified applicants will receive consideration for employment without regard to race, sex color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.Apply for this job
First Name * Last Name * Email * Phone * Resume/CV * Accepted file types: pdf, doc, docx, txt, rtfLinkedIn Profile Website Are you comfortable working in a hybrid setting? * Are you willing to undergo a background check, in accordance with local law/regulations? * Work Authorization: Are you legally authorized to work in the United States? *Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.Select...Voluntary Self-Identification of Disability
Form CC-305OMB Control Number 1250-0005 Expires 04/30/2026Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one.How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to:Alcohol or other substance use disorder (not currently using drugs illegally)Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDSBlind or low visionCancer (past or present)Cardiovascular or heart diseaseCeliac diseaseCerebral palsyDeaf or serious difficulty hearingDiabetesDisfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disordersEpilepsy or other seizure disorderGastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndromeIntellectual or developmental disabilityMental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSDMissing limbs or partially missing limbsMobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supportsNervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilitiesPartial or complete paralysis (any cause)Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysemaShort stature (dwarfism)Traumatic brain injuryPUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
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