University of Pennsylvania
Senior Research Investigator (Department of Neurosurgery)
University of Pennsylvania, Phila, Pennsylvania, United States, 19117
Senior Research Investigator (Department of Neurosurgery)
University OverviewThe University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer, Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.Posted Job TitleSenior Research Investigator (Department of Neurosurgery)Job Profile TitleResearch Investigator, SeniorJob Description SummaryOur Penn Neurosurgery lab at The University of Pennsylvania is seeking an enthusiastic, dedicated, and highly motivated Senior Research Investigator to serve in a leadership role in managing the Translational Neurosurgical Oncology Lab under the direction of Dr. Nduka Amankulor (Director of the Penn Brain Tumor Center, Division Head of Neurosurgical Oncology and Cancer Moonshot Scholar). The goal of the Amankulor Lab For Brain Tumor Immunogenetics is to understand mechanisms of immune evasion by primary malignant brain tumors adult and pediatric gliomas. We seek a Senior Research Investigator to play a leading role in developing a research program in the advancement of our research pursuit and will play a crucial role both in all aspects of research products including development, implementation, and data analysis.Job DescriptionThe focus of our lab's research is at the intersection of immunology, genetics, and brain tumor biology. The primary goal of our translational research is to understand mechanisms of immune evasion by primary malignant brain tumors, to generate detailed knowledge regarding the immunologic functions of distinct cell types in primary brain tumors, to capture novel immunologic consequences of distinct glioma genotypes, and to build novel oncoimmunologic therapies ranging from pharmacologic therapies to cell, vaccine, and antibody therapies. Our lab has developed a thorough, multi-pronged approach to study the problems stated above, and we utilize novel transcriptional, proteomic, and chromatin-based platforms to identify distinct immune cell fates and functions. More importantly, we are, at our core, a brain tumor biology lab and we evaluate immuno-genomic dysfunction in brain tumors by leveraging high fidelity murine models genetically engineered to recapitulate this disease. As a consequence of the breadth of our studies, we utilize basic immunologic platforms (flow cytometry, immune-based cytotoxicity assays, lymphocyte and myeloid cell functional assays, and standard wet lab approaches including western blotting, ELISA, and immune receptor-ligand binding assays). Our target cells are myeloid, T cells, and NK cells. Our approach is determined by tumor-specific genetic alterations that drive these events. Thus, our lab has two unique streams of discovery: 1) mechanistic elucidation of genotype-specific immune states; 2) identification of tumor and genotype-specific immunotherapeutic modalities; and 3) characterization of novel immunologic states that guide tumor-stromal and tumor-bone marrow/peripheral blood interactions. Since our laboratory has already discovered novel therapies currently under investigation at the Penn Brain Tumor Center, a substantial amount of effort is also devoted to the identification of immunologic biomarkers.Position contingent upon funding.Job ResponsibilitiesLeading the implementation of experimental projects design of the translational/basic science experiments to test hypotheses related to our research goals using in vitro (cell culture/organoids), in vivo animal models, and primary patient samples.Learning novel computational platforms required for analysis of single, bulk, and multiplatform, chromatin, RNA, proteomic, and metabolic profiles.Thorough data analysis, manuscript preparation, responsibilities related to grant preparation.Leadership roles related to supervision of more junior lab members.Ensuring day-to-day operations of the lab and reporting deleterious behavior to the PI.Commitment to a pathway to full independence within 3-5 years of assuming the current position.Organizing lab meetings and ensuring that individual lab members are ready for their presentations at weekly lab meetings. The above criteria, by definition, require a dynamic, organized, ethical, and highly skilled scientist for whom the current role is not terminal but a starting position for greater individual achievement.QualificationsDoctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.The position requires excellent communication and interpersonal skills, a highly motivated, independent thinker and worker, with a desire to work in a complex and high energy environment. Preference will be given to individuals with experience in omics (transcriptomics and computational skills), immunologic assays, and expertise in animal experiments/creation of novel genetic models. Successful candidates will have a demonstrated track record of project completion and publications, as well as a high level of scientific rigor and a reasonable number of first-author publications in journals above impact factor of 8 will present a significant advantage for candidates.Job Location - City, StatePhiladelphia, PennsylvaniaDepartment / SchoolPerelman School of MedicinePay Range$36,368.00 - $94,753.00 Annual Rate. Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.Affirmative Action StatementPenn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.Special RequirementsBackground check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.To apply, visit
this link
#J-18808-Ljbffr
University OverviewThe University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer, Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.Posted Job TitleSenior Research Investigator (Department of Neurosurgery)Job Profile TitleResearch Investigator, SeniorJob Description SummaryOur Penn Neurosurgery lab at The University of Pennsylvania is seeking an enthusiastic, dedicated, and highly motivated Senior Research Investigator to serve in a leadership role in managing the Translational Neurosurgical Oncology Lab under the direction of Dr. Nduka Amankulor (Director of the Penn Brain Tumor Center, Division Head of Neurosurgical Oncology and Cancer Moonshot Scholar). The goal of the Amankulor Lab For Brain Tumor Immunogenetics is to understand mechanisms of immune evasion by primary malignant brain tumors adult and pediatric gliomas. We seek a Senior Research Investigator to play a leading role in developing a research program in the advancement of our research pursuit and will play a crucial role both in all aspects of research products including development, implementation, and data analysis.Job DescriptionThe focus of our lab's research is at the intersection of immunology, genetics, and brain tumor biology. The primary goal of our translational research is to understand mechanisms of immune evasion by primary malignant brain tumors, to generate detailed knowledge regarding the immunologic functions of distinct cell types in primary brain tumors, to capture novel immunologic consequences of distinct glioma genotypes, and to build novel oncoimmunologic therapies ranging from pharmacologic therapies to cell, vaccine, and antibody therapies. Our lab has developed a thorough, multi-pronged approach to study the problems stated above, and we utilize novel transcriptional, proteomic, and chromatin-based platforms to identify distinct immune cell fates and functions. More importantly, we are, at our core, a brain tumor biology lab and we evaluate immuno-genomic dysfunction in brain tumors by leveraging high fidelity murine models genetically engineered to recapitulate this disease. As a consequence of the breadth of our studies, we utilize basic immunologic platforms (flow cytometry, immune-based cytotoxicity assays, lymphocyte and myeloid cell functional assays, and standard wet lab approaches including western blotting, ELISA, and immune receptor-ligand binding assays). Our target cells are myeloid, T cells, and NK cells. Our approach is determined by tumor-specific genetic alterations that drive these events. Thus, our lab has two unique streams of discovery: 1) mechanistic elucidation of genotype-specific immune states; 2) identification of tumor and genotype-specific immunotherapeutic modalities; and 3) characterization of novel immunologic states that guide tumor-stromal and tumor-bone marrow/peripheral blood interactions. Since our laboratory has already discovered novel therapies currently under investigation at the Penn Brain Tumor Center, a substantial amount of effort is also devoted to the identification of immunologic biomarkers.Position contingent upon funding.Job ResponsibilitiesLeading the implementation of experimental projects design of the translational/basic science experiments to test hypotheses related to our research goals using in vitro (cell culture/organoids), in vivo animal models, and primary patient samples.Learning novel computational platforms required for analysis of single, bulk, and multiplatform, chromatin, RNA, proteomic, and metabolic profiles.Thorough data analysis, manuscript preparation, responsibilities related to grant preparation.Leadership roles related to supervision of more junior lab members.Ensuring day-to-day operations of the lab and reporting deleterious behavior to the PI.Commitment to a pathway to full independence within 3-5 years of assuming the current position.Organizing lab meetings and ensuring that individual lab members are ready for their presentations at weekly lab meetings. The above criteria, by definition, require a dynamic, organized, ethical, and highly skilled scientist for whom the current role is not terminal but a starting position for greater individual achievement.QualificationsDoctor of Medicine, Doctor of Philosophy, and 5 to 7 years of postdoctoral experience is required.The position requires excellent communication and interpersonal skills, a highly motivated, independent thinker and worker, with a desire to work in a complex and high energy environment. Preference will be given to individuals with experience in omics (transcriptomics and computational skills), immunologic assays, and expertise in animal experiments/creation of novel genetic models. Successful candidates will have a demonstrated track record of project completion and publications, as well as a high level of scientific rigor and a reasonable number of first-author publications in journals above impact factor of 8 will present a significant advantage for candidates.Job Location - City, StatePhiladelphia, PennsylvaniaDepartment / SchoolPerelman School of MedicinePay Range$36,368.00 - $94,753.00 Annual Rate. Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.Affirmative Action StatementPenn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.Special RequirementsBackground check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.To apply, visit
this link
#J-18808-Ljbffr